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目的:观察延长服用参蛤胶囊治疗慢性阻塞性肺疾病患者的临床疗效。方法:选取127例慢性阻塞性肺疾病患者作为研究对象,所有患者服药后进行随访24个月,观察服药后6个月、12个月、18个月、24个月患者的症状缓解情况及其它方面的变化。结果:延长患者服用参蛤胶囊6个月、12个月、18个月及24个月,COPD评估测试(CAT)得分逐渐降低;24个月后为(12.6±1.2)分,住院频率由初始的(1.3±0.2)次/6个月降低到(0.7±0.1)次/6个月;生活质量满意度评分随着症状的减轻逐渐提高,与开始服药时比较差异具有统计学意义(P<0.05),研究中仅1例患者出现轻微胃肠道反应。结论:延长服用参蛤胶囊疗程可减轻患者慢性阻塞性肺疾病临床症状,减少住院频率,改善生活质量,降低不良反应发生率,值得临床推广应用。
OBJECTIVE: To observe the clinical effect of prolonged taking Shen-clam capsule in patients with chronic obstructive pulmonary disease. Methods: A total of 127 patients with chronic obstructive pulmonary disease (COPD) were enrolled in this study. All patients were followed up for 24 months after taking the drug. The patients’ symptoms were observed at 6 months, 12 months, 18 months and 24 months after treatment Changes in the area. Results: The prolonged patients took SHENGMA capsules at 6 months, 12 months, 18 months and 24 months. The scores of COPD decreased (12.6 ± 1.2) after 24 months. The frequency of hospitalization changed from initial (1.3 ± 0.2) times / 6 months to (0.7 ± 0.1) times / 6 months. The score of satisfaction of life quality gradually increased with the alleviation of symptoms, which was significantly different from that at the beginning of medication (P < 0.05). Only 1 patient in the study developed a mild gastrointestinal reaction. Conclusion: Taking Shenma capsule can prolong the clinical symptoms of chronic obstructive pulmonary disease, reduce the frequency of hospitalization, improve the quality of life and reduce the incidence of adverse reactions, which is worthy of clinical application.