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目的:探讨米非司酮与米索前列醇不同用法在重复无痛人流术中的应用。方法:回顾性分析上海市普陀区妇婴保健院2011至2012年行重复无痛人流术者250例及我院2012年行重复无痛人流术者50例的临床资料。A组100例术前晚20:00口服米非司酮100 mg,B组100例术前2 h阴道后穹窿放置米索前列醇400μg,C组100例术前晚20:00口服米非司酮100 mg、术前2 h舌下含服米索前列醇400μg;观察3组病例术前、术中、术后各方面的差异。结果:3组在宫颈软化、麻醉效果、术后宫颈粘连发生率方面比较差异无统计学意义(P>0.05),C组在术前胃肠道不适、手术时间、术中出血量方面与A、B组比较差异有统计学意义(P<0.05),A组术后阴道流血时间与B、C组比较差异有统计学意义(P<0.05)。结论:米非司酮配伍米索前列醇值得推广应用到所有高危人流术中。
Objective: To explore the different usage of mifepristone and misoprostol in repeated painless abortion. Methods: The clinical data of 250 cases of repeated painless abortion in our hospital from 2005 to 2012 in Putuo District of Shanghai and 50 cases of repeat painless abortion in our hospital in 2012 were analyzed retrospectively. A group of 100 patients preoperative 20:00 oral mifepristone 100 mg, 100 cases of group B 2 hours before surgery to place vaginal fornix misoprostol 400μg, 100 cases of group C 20:00 oral preoperative mifei Ketone 100 mg, 2 h preoperative sublingual misoprostol 400μg; observed three groups of patients preoperative, intraoperative and postoperative differences in all aspects. Results: There was no significant difference between the three groups in terms of cervical softening, anesthesia effect and incidence of postoperative cervical adhesions (P> 0.05). There was no significant difference between the three groups in terms of preoperative gastrointestinal discomfort, operation time and intraoperative blood loss (P <0.05). The time of vaginal bleeding after operation in group A was significantly different from that in group B and C (P <0.05). Conclusion: The combination of mifepristone and misoprostol should be widely used in all high-risk abortion patients.