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AIM:To elucidate the age-distribution of anti-hepatitis A virus(HAV) seroprevalence across different socioeconomic status(SES) categories in Bangladesh which,despite scarce data,is generally deemed to have high endemicity.METHODS:Blood samples of 818 subjects from a stratified sample of schools and hospitals,comprising different age categories and SES were collected.They were assayed for total anti-HAV antibodies.Social and medical history data were obtained using a questionnaire.RESULTS:Overall anti-HAV seroprevalence was 69.6%,increasing with age from 1-5 years(40.4%) to >30 years(98.4%).Seroprevalence was lowest(49.8%) in the high SES group and highest(96.5%) in the rural lower-middle SES group.Among subjects aged 6-20 years,anti-HAV seroprevalence was lowest in urban private school children(43.0%),followed by urban government school children(76.2%) and rural school children(96.5%)(P<0.01).Within the high SES group,anti-HAV seroprevalence was 32.3% in subjects <10 years and 51.7% in those aged 11-20 years.Until now Bangladesh has been deemed to have high endemicity for HAV.CONCLUSION:The transition from high to intermediate HAV endemicity may be underway;high SES adolescents and adults remain particularly at risk of symptomatic illness.Preventive measures need consideration.
AIM: To elucidate the age-distribution of anti-hepatitis A virus (HAV) seroprevalence across different socioeconomic status (SES) categories in Bangladesh which, despite scarce data, is generally deemed to have high endemicity. METHODS: Blood samples of 818 subjects from A stratified sample of schools and hospitals, including different age categories and SES were collected. The were assayed for total anti-HAV antibodies. Social and medical history data were obtained using a questionnaire .RESULTS: Overall anti-HAV seroprevalence was 69.6%, increasing with age from 1-5 years (40.4%) to> 30 years (98.4%). Seroprevalence was lowest (49.8%) in the high SES group and highest (96.5%) in the rural lower-middle SES group. Among subjects aged 6-20 years, anti-HAV seroprevalence was lowest in urban private school children (43.0%) followed by urban government school children (76.2%) and rural school children (96.5%) (P <0.01) .Within the high SES group , anti-HAV seroprevalence was 32.3% in subjects <10 years and 51.7% in those aged 11-20 years. Until now Bangladesh has been been to to high endemicity for HAV. CONCLUSION: The transition from high to intermediate HAV endemicity may be underway; high SES adolescents and adults remain particularly at risk of symptomatic illness. Preventive measures need consideration.