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目的 :探讨经血传播病毒 (TTV)在南京地区分子流行学状况及TTV可能的传播途径。方法 :选择各型病毒性肝炎 975例 ,献血员 30例 ,慢性肾功能衰竭长期血透者 1 50例及健康者 32例作为研究对象 ,用n -PCR法检测各种人群中 (TTVDNA)的感染情况。并研究TTVDNA阳性与输血的关系。结果 :在各种人群中TTVDNA的检出率分别为非甲～庚型肝炎 2 2 % ,病毒性肝炎 1 3 .9% ,献血员 33 .3 % ,长期血透者 2 7.3 % ,健康人 9.4% ,1 36例TTVDNA阳性病毒性肝炎患者仅 1 9.9% (2 7/ 1 36)有输血史。结论 :献血员及其它经常接触血制品的人群是TTV感染的高危人群 ,输血是TTV感染的途径之一 ,肠道传播可能也是TTV传播的一条途径
Objective: To investigate the molecular epidemiology of menstrual transmission virus (TTV) in Nanjing and possible transmission of TTV. Methods: 975 cases of various types of viral hepatitis, 30 blood donors, chronic hemodialysis patients with chronic renal failure and 50 healthy subjects were selected as research objects. The n-PCR method was used to detect TTVDNA Infection. And study the relationship between TTVDNA positive and blood transfusion. Results: The detection rates of TTVDNA in various population were 22% of non-A ~ G hepatitis, 13.9% of viral hepatitis, 33.3% of blood donors, 23.3% of long-term hemodialysis patients, healthy persons 9.4%. Only 1 9.9% (27/36) of 136 TTV DNA positive viral hepatitis patients had a history of blood transfusions. CONCLUSIONS: Blood donors and other people who have frequent contact with blood products are at high risk for TTV infection. Blood transfusion is one of the pathways for TTV infection and gut transit may also be a pathway for the spread of TTV