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本文报告对16例外科择期手术患者术前、术后血小板聚集功能变化的观察结果。发现术后血小板聚集功能改变主要表现在血小板对诱聚剂 ADP、Adr 引起的聚集速率(ADP 1′A;Adr 1′A、Vmax)指标较术前有明显变化;血小板对 Adr的反应比 ADP 更为敏感。本组实验结果还表明,虽然手术后血小板对肾上腺素的反应性增加,但并未就此引起血小板聚集功能亢进而促成高凝状态。另一方面,肾上腺功能的增强可能带来血液粘度的增加,有可能形成局部血栓而发生 DVT,值得进一步研究。
This article reports on 16 cases of surgical elective surgery in patients with preoperative and postoperative changes in platelet aggregation observed results. Found that postoperative changes in platelet aggregation mainly in the platelet on the ADP, Adr induced aggregation rate (ADP 1’A; Adr 1’A, Vmax) indicators were significantly changed compared with the preoperative; platelet response to Adr than ADP More sensitive. The experimental results in this group also showed that although postoperative reactivity of platelets to epinephrine increased, but did not cause platelet aggregation over hyperthyroidism contributed to hypercoagulable state. On the other hand, increased adrenal function may lead to increased blood viscosity, the possibility of local thrombosis and the occurrence of DVT, deserves further study.