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目的:观察不同部位胃癌(贲门癌与非贲门癌)组织中肿瘤相关巨噬细胞(tumor associated macrohags,TAMs)的表达及其与血管生成的关系,并进一步分析其与临床病理特征的相关性。方法:利用免疫组化方法标记TAMs(抗CD68抗体)和血管内皮细胞(抗CD34抗体),检测90例胃癌中(包括18例贲门癌与72例非贲门癌)TAMs、微血管密度(microvessel density,MVD)的表达情况。结果:①TAMs与胃癌的部位、分化程度、浸润深度及临床分期呈显著正相关(P均<0.05);②MVD与胃癌的部位和分化程度呈显著正相关(P<0.05);结论:TAM可以促进胃癌的发展,这可能与TAM促进肿瘤的血管生成有关;TAM的表达可能是影响贲门癌与非贲门癌生物学行为差异的因素之一。
OBJECTIVE: To observe the expression of Tumor Associated Macrophages (TAMs) and their relationship with angiogenesis in gastric cancer (cardia carcinoma and non-cardiac carcinoma) at different sites and further analyze their correlation with clinicopathological features. Methods: TAMs (anti-CD68 antibody) and anti-CD34 antibody were labeled by immunohistochemistry. TAMs and microvessel density in 90 cases of gastric cancer including 18 cases of cardia and 72 cases of non- MVD) expression. Results: (1) There was a significant positive correlation between TAMs and the location, differentiation, depth of invasion and clinical stage (P <0.05); (2) There was a significant positive correlation between MVD and the location and differentiation of gastric cancer (P <0.05) Gastric cancer, which may be related to TAM promoting tumor angiogenesis; TAM expression may be one of the factors that affect the biological behavior of cardia cancer and non-cardia cancer.