诊断恶性黑素瘤（下称恶黑）时首先要强调肉眼病理变化，然后是扫视镜头及高倍镜下所见，最后综合分析、作出判断。但有些疑难病例仍需要采用组织化学、免疫组化、定量形态学、甚至分子生物学方法进一步研究。一、肉眼病理变化检查肉眼病变十分必要，主要改变为病损不规则... When the diagnosis of malignant melanoma (hereinafter referred to as malignant black), we must first emphasize the pathological changes of the naked eye, and then the saccade lens and the high-power microscope to see, and finally comprehensive analysis and make judgments. However, some difficult cases still require further research using histochemistry, immunohistochemistry, quantitative morphology, and even molecular biology methods. First, the pathological changes of the naked eye to check the gross lesions is very necessary, mainly to irregular lesions ...