目的:进一步优化益心舒胶囊质量控制方法。方法:采用薄层色谱法对人参、丹参、五味子和黄芪进行定性鉴别;用UPLC对人参皂苷Rg1,Re进行含量测定。结果:本品定性薄层色谱斑点清晰,专属性强;人参皂苷Rg1在进样量为在0.3982~3.9931μg呈良好的线性关系(r=0.999 9),人参皂苷Re在进样量为0.3935~3.9566μg呈良好的线性关系(r=0.9999);人参皂苷Rg1、人参皂苷Re加样回收率平均达99.1%,RSD1.2%。结论:该方法准确灵敏、简便、重复性好,提高后的质量标准能更有效的控制益心舒胶囊的质量。 Objective: To further optimize the method of quality control of Yixinshu capsule. Methods: Thin layer chromatography was used to qualitatively identify ginseng, salvia miltiorrhiza, Schisandra chinensis and Astragalus membranaceus. The contents of ginsenosides Rg1 and Re were determined by UPLC. Results: The qualitative TLC spots were clear and specific. Ginsenoside Rg1 had a good linear relationship (r = 0.999 9) at the injection volume of 0.3982-3.99931μg, ginsenoside Re at the injection volume of 0.3935 ~ 3.9566μg showed a good linear relationship (r = 0.9999). The recoveries of ginsenoside Rg1 and ginsenoside Re were 99.1% and RSD 1.2%, respectively. Conclusion: The method is accurate, sensitive, simple and reproducible. The improved quality standard can effectively control the quality of Yixinshu capsule.