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目的 支气管肺泡灌洗术 (BAL)能否治疗矽肺仍有异议 ,进行其实验研究 ,可为临床治疗提供科学依据。方法 观察各组大鼠BAL后的组织学改变 ,用免疫细胞化学法观察其肺巨噬细胞数量的变化。结果 染尘后的大鼠肺 ,经灌洗后肺泡腔内容物减少 ,肺泡隔厚度变薄 ,肺组织的细胞密度较前下降 (包括肺泡腔及肺泡隔中的巨噬细胞数 ) ,且差别有显著意义 (P <0 .0 1)。肺间质的粉尘 ,可通过清除肺泡隔内的巨噬细胞而清出。结论 BAL对延缓矽肺病变的发生、发展起积极作用。
Objective Whether bronchial alveolar lavage (BAL) can treat silicosis remains controversial and its experimental study may provide a scientific basis for clinical treatment. Methods The histological changes of BAL in each group were observed and the changes of the number of macrophages in lung were observed by immunocytochemistry. Results After the lungs were dyed, the contents of the alveolar space decreased after lavage, the thickness of the alveolar septum became thinner and the density of the lung tissue decreased (including the number of macrophages in the alveolar space and alveolar septa) Significant (P <0. 01). Pulmonary interstitial dust, by clearing the alveolar septa of macrophages and clear. Conclusion BAL can play an active role in delaying the occurrence and development of silicosis.