The cooling rate sensitivities of Al Ti B, RE and Al Ti B–RE refiners were investigated using laboratory experiments and the actual industrial applications of A356 automotive wheel via low pressure die casting technology. Their impact mechanisms on the microstructure and mechanical properties of the A356 alloy were discussed. The results demonstrated that the Al Ti B–RE refiner possessed most effective and synergetic refinement effects compared to the individual Al Ti B or RE refiners. The Al Ti B–RE refiner exhibited the least sensitivity to the cooling rate changes than the other refiners. The comprehensive properties of alloy wheel refined by the Al Ti B–RE refiner were improved significantly.The tensile strength, yield strength, and elongation of wheel spoke improved by approximately 11.3%, 10.8% and 44.1%,respectively. The property difference values of the tensile strength, yield strength, and elongation in different positions of the wheel decreased from 14.8%, 31.2% and 47.7% to 8.6%, 27.1% and 30.9%, respectively. The cooling rate sensitivities of Al Ti B, RE and Al Ti B-RE refiners were investigated using laboratory experiments and the actual industrial applications of A356 automotive wheel via low pressure die casting technology. Their impact mechanisms on the microstructure and mechanical properties of the A356 The results were that that the Al Ti B-RE refiner possessed most effective and synergetic refinement effects compared to the individual Al Ti B or RE refiners. The Al Ti B-RE refiner exhibited the least sensitivity to the cooling rate changes than the other refiners. The comprehensive properties of alloy wheel refined by the Al Ti B-RE refiner were improved significantly. tensile strength, yield strength, and elongation of wheel spoke improved by approximately 11.3%, 10.8% and 44.1%, respectively. property difference values ​​of the tensile strength, yield strength, and elongation in different positions of the wheel decreased from 14.8%, 31.2% and 4 7.7% to 8.6%, 27.1% and 30.9% respectively.