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[目的]探讨童年虐待对精神分裂症患者血清瘦素(LP)水平的影响.[方法]选择2016年1月至2017年6月本院收治的112例首次发病的精神分裂症患者为研究对象,应用童年创伤问卷(CTQ)评估童年受虐程度和种类,根据CTQ评分结果分为受虐组(n=40)和非受虐组(n =72).采用阳性与阴性症状量表(PANSS)评估患者的精神症状;采用 ELISA法检测血清 LP、5-羟色胺(5-HT)和脑源性神经营养因子(BDNF)水平.[结果]受虐组和非受虐组男女比例、首发年龄方面比较,差异具有统计学意义(P 0.05).受虐组CTQ总分及情感虐待、情感忽视、性虐待、躯体虐待和躯体忽视得分均显著高于非受虐组,差异具有统计学意义(P <0.05).受虐组PANSS总分及一般病理、阳性症状、阴性症状得分均显著高于非受虐组,差异具有统计学意义(P <0.05).受虐组血清 LP、5-HT水平显著低于非受虐组,差异具有统计学意义(P 0.05).Spearman 相关分析显示,CTQ评分与PANSS评分呈显著正相关(r=0.536,P =0.032<0.05),CTQ总分与 LP 呈显著负相关(r =-0.511, P =0.039<0.05).[结论]存在童年虐待的精神分裂症患者女性多于男性,且精神分裂症首发年龄更早,临床症状更严重,而受虐患者血清 LP、5-HT水平与非受虐患者存在差异,在一定程度上影响精神分裂症的发生.“,”[Objective]To investigate the effect of childhood abuse on serum leptin in schizophrenic patients.[Meth-ods]A total of 112 patients with schizophrenia were enrolled in our hospital from January 2016 to June 2017.The Child-hood Trauma Questionnaire (CTQ)was used to assess the extent and type of child abuse.According to CTQ scores,1 12 patients were divided into abused group (n=40)and non-abused group (n=72).The psychiatric symptoms were as-sessed using the Positive and Negative Symptom Scale(PANSS).Serum levels of leptin,serotonin(5-HT)and brain-de-rived neurotrophic factor (BDNF)were measured by ELISA.[Results]There were statistically significant differences in the starting age of abuse,and the proportion of male and female victims between the abused and non-abused groups (P0.05).The total score of CTQ and scores of emotional abuse,affective neglect,sexual abuse,physical abuse and physical neglect were significantly high-er in the abused group than those of non-abused group (P <0.05).The total score of PANSS and scores of general pa-thology,positive symptoms and negative symptoms were significantly higher in the abused group than those of non-a-bused group(P<0.05).The levels of serum LP and 5-HT in the abused group were significantly lower than those in the non-abused group (P 0.05).Spearman correlation analysis showed that there was a significant positive correlation between CTQ score and PANSS score (r=0.536,P =0.032<0.05).There was a significant negative correlation between CTQ total score and LP (r=-0.511,P =0.039<0.05).[Conclusion]There are more female schizophrenia than male schizophrenia cases caused by childhood abuse.The earlier age of receiving abuse,the more severe clinical symptoms exist.The difference of serum LP and 5-HT levels between the abuse and non-abuse groups reflects the occurrence of schizophrenia.