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临床无急性冠状动脉综合征症状的终末期肾病(ESRD)者中,相当数量的患者血清心脏肌钙蛋白水平不同程度地升高,其中心脏型肌钙蛋白T(cTnT)升高的发生率高于心脏型肌钙蛋白I(cTnI)。最初认为这是血清肌钙蛋白非特异性升高,或认为是心外来源,无临床预测价值。随后的研究认为,ESRD患者血清肌钙蛋白升高可能是各种原因引起的心肌微损伤或微梗死,导致心肌cTnT与cTnI释放入血清的结果,具有肯定的预后意义,能提供某些准确的预后信息。鉴于在ESRD患者血清肌钙蛋白升高机制及临床意义方面存在分歧,应进行更深入的研究。
Serum levels of cardiac troponin were elevated to varying degrees in patients with end-stage renal disease (ESRD) who did not have clinical symptoms of acute coronary syndrome, with a high incidence of elevated cardiac troponin T (cTnT) In cardiac troponin I (cTnI). This was initially thought to be non-specific elevation of serum troponin or was considered extracardiac and had no clinically predictive value. Subsequent studies suggest that elevated serum troponin in patients with ESRD may be caused by a variety of causes of myocardial micro-damage or micro-infarction, resulting in myocardial cTnT and cTnI released into the serum results have a positive prognostic significance, to provide some accurate Prognosis information. In the light of differences in the mechanism of serum troponin elevation in ESRD patients and their clinical implications, further studies should be conducted.