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慢性稳定型心绞痛心肌缺血的原因包括心肌耗氧量增加和血流减少。β阻滞剂主要通过减少心肌需氧量而控制缺血发作,钙拮抗剂控制缺血则通过改善心肌氧供应。两者并用时控制心肌缺血效果增强。冠脉造影确诊的23例慢性稳定型心绞痛,运动试验均阳性。停用抗心绞痛药,以随机、交叉方式口服阿替洛尔50mg每日2次和缓释型硝苯啶20mg每日2次或两药并用,各治疗3周。治疗前,运动引起心电图ST段下降1mm的时间为7.4±0.8分钟,运动引起ST段下降1mm时心率-血压乘积为20041±1046beat/min·mmHg,动态心电图总缺血
Causes of myocardial ischemia in chronic stable angina include increased myocardial oxygen consumption and decreased blood flow. Beta blockers control ischemic attacks primarily by reducing myocardial oxygen demand, whereas calcium antagonists control ischemia by improving myocardial oxygen supply. Both use and control of myocardial ischemia increased. Coronary angiography confirmed 23 cases of chronic stable angina, exercise test were positive. Anti-anginal drug withdrawal, a randomized, crossover oral administration of atenolol 50mg twice daily and extended-release nifedipine 20mg 2 times a day or two and use, each treatment for 3 weeks. Before treatment, exercise-induced electrocardiogram ST segment decreased 1mm time was 7.4 ± 0.8 minutes, exercise-induced ST segment decreased 1mm heart rate - pressure product of 20041 ± 1046beat / min · mmHg, total electrocardiogram total ischemia