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目的:通过对心理性ED患者脑白质纤维的二值化和加权网络节点度和连接强度拓扑属性值的探讨,分析不同脑区所连接白质纤维髓鞘完整性、数目及其长度在拓扑空间上的改变情况。方法:采集21例心理性ED患者及性别、年龄、受教育程度相匹配的24例对照者的弥散张量成像数据;对所有数据进行预处理,将整个大脑划分为90个区域,追踪全脑白质纤维,构建全脑白质的二值化和加权网络,计算脑区的度和连接强度属性值;对组间属性值进行独立双样本t检验,并对结果进行多重校正,将差异属性值与患者阴茎勃起功能进行皮尔森相关分析。结果:1患者组脑白质二值化网络中左侧三角部额下回(5.95±1.28,7.54±1.44,t=-3.88,P=0.02)、内侧眶部额上回(6.29±3.30,10.08±3.60,t=-3.67,P=0.02)、杏仁核(4.29±1.31,6.50±2.11,t=-4.16,P=0.01)度较对照组(均为校正后P值)显著下降;2患者组基于FA值的脑白质加权网络中左侧三角部额下回(1.72±0.50,2.50±0.68,t=-4.35,P=0.01)、内侧眶部额上回(2.08±1.10,3.17±0.97,t=-3.53,P=0.03)、杏仁核(1.11±0.39,1.80±0.69,t=-4.03,P=0.01)连接强度也均较对照组(均为校正后P值)显著下降;3患者组基于FA值的脑白质加权网络中左侧三角部额下回(1.72±0.50)、内侧眶部额上回(2.08±1.10)、杏仁核(1.11±0.39)连接强度也均较对照组(2.50±0.68,t=-4.35,P=0.01;3.17±0.97,t=-3.53,P=0.03;1.80±0.69,t=-4.03,P=0.01,校正后P值)显著下降;4患者左侧杏仁核度属性值与勃起功能国际问卷总分(r=-0.47,P=0.04)、第2项评分(r=-0.46,P=0.03)以及第3项评分(r=-0.45,P=0.04)均呈负相关。结论:心理性ED患者左侧部分额叶和杏仁核所连接的白质纤维髓鞘完整性受损害,导致患者产生情绪、处理及调控的异常,另外患者左侧杏仁核所连接的白质纤维在大脑信息传递活动中的中心地位和重要性的下降可能与心理性ED相关。
OBJECTIVE: To investigate the topological properties of white matter fibers in white matter fibers of brain in ED patients and to explore the relationship between the number of white matter fibers and their length in topological space Change situation. Methods: Twenty-two patients with psychological ED were enrolled in this study. Twenty-four healthy controls matched for sex, age and educational attainment were used for diffusion tensor imaging. All data were preprocessed and the entire brain was divided into 90 regions. White matter fibers were used to construct a binarized and weighted network of whole white matter and calculate the degree and connection strength of brain regions. Independent two-sample t-test was performed on the attribute values between groups and multiple corrections were performed. Pearson correlation analysis of patients with penile erection. Results: In the 1 patient group, the amount of leftward trigonometry was lower in the left triangle (5.95 ± 1.28, 7.54 ± 1.44, t = -3.88, P = 0.02) (3.29 ± 1.31, 6.50 ± 2.11, t = -4.16, P = 0.01) were significantly lower than those in the control group (both corrected P values); 2 patients The values of the left inferior frontal triangle (1.72 ± 0.50, 2.50 ± 0.68, t = -4.35, P = 0.01), the medial orbital superior forehead (2.08 ± 1.10, 3.17 ± 0.97 , t = -3.53, P = 0.03), the amygdala (1.11 ± 0.39,1.80 ± 0.69, t = -4.03, P = 0.01) were also significantly decreased compared with the control group Compared with the control group, in the left ventricle of the white matter weighted network, the lower frontal cortex (1.72 ± 0.50), the medial orbital frontal front (2.08 ± 1.10) and the amygdala (1.11 ± 0.39) (2.50 ± 0.68, t = -4.35, P = 0.01; 3.17 ± 0.97, t = -3.53, P = 0.03; 1.80 ± 0.69, t = -4.03, P = (R = -0.47, P = 0.04), the second score (r = -0.46, P = 0.03) and the third score (r = -0.45, P = 0.04) were negatively correlatedConclusions: The integrity of the myelin sheath of white matter fibers connected with left frontal lobe and amygdala in psychological ED patients is impaired, resulting in abnormalities in mood, handling and regulation. In addition, white matter fibers linked by the left amygdala in patients with cerebellar The decline in the centrality and importance of information delivery activities may be related to psychological ED.