论文部分内容阅读
目的 探讨愈肝汤对慢性乙肝患者的脂质过氧化作用。方法 43例慢性乙肝患者服愈肝汤治疗 3mo ,观察其治疗前后超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH -Px)活力和过氧化脂质(LPO)水平的变化 ,并与 38例健康对照组比较。结果 慢性乙肝患者SOD、GSH -Px活力降低 (P <0 .0 5 ) ,LPO水平升高 (P <0 .0 5 ) ;愈肝汤可升高SOD和GSH -Px酶活性 (P <0 .0 1) ,降低LPO水平 (P <0 .0 5 )。结论 愈肝汤对慢性乙肝患者有明显的抗脂质过氧化作用 ,这是其治疗慢性乙型肝炎、减轻肝细胞损伤的重要机理之一。
Objective To investigate the effect of Yugan decoction on lipid peroxidation in chronic hepatitis B patients. Methods Forty-three patients with chronic hepatitis B were given Fugangan decoction for 3 months. The levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and lipid peroxidation (LPO) before and after treatment were observed Changes, and compared with 38 healthy controls. Results The activity of SOD and GSH-Px in chronic hepatitis B patients were decreased (P <0.05), LPO level was increased (P <0.05), Yugan decoction could increase the activities of SOD and GSH-Px .0 1), and lower the level of LPO (P <0.05). Conclusion Yugan Decoction has obvious anti-lipid peroxidation effect on chronic hepatitis B patients, which is one of its important mechanisms in the treatment of chronic hepatitis B and the alleviation of hepatocellular injury.