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目的 了解大剂量甲基强的松龙冲击前后肾小球疾病患儿尿Ⅳ型胶原含量的变化 ,探讨其临床意义。方法 应用ELISA法监测大剂量甲基强的松龙冲击前后 8例肾小球疾病患儿尿Ⅳ型胶原含量的变化。结果 冲击前其尿Ⅳ型胶原含量明显高于对照组 ,经过一个疗程甲基强的松龙冲击治疗后 1d ,患儿尿Ⅳ型胶原含量较冲击前明显下降 (P <0 .0 1)。结论 甲基强的松龙冲击治疗可影响肾小球疾病尿Ⅳ型胶原含量
Objective To investigate the changes of urinary type Ⅳ collagen in children with glomerular disease before and after high-dose methylprednisolone impact and to investigate its clinical significance. Methods The changes of urinary type Ⅳ collagen in 8 cases of glomerular diseases before and after high dose methylprednisolone were measured by ELISA. Results The urinary type Ⅳ collagen content before impact was significantly higher than that of the control group. After a course of methylprednisolone treatment for 1 day, urinary level of type Ⅳ collagen in children decreased significantly (P <0.01) before impact. Conclusion Methylprednisolone impact treatment can affect the urinary type Ⅳ collagen content in glomerular diseases