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目的探讨脑梗塞患者红细胞膜脂质成分改变及其与血粘度的关系。方法对５８例脑梗塞患者和２６名健康人的红细胞膜脂质成分、全血粘度进行了测定。结果患者红细胞膜胆固醇（ＣＨＯ）含量升高，磷脂酰胆碱（ＰＣ）、磷脂酰乙醇胺（ＰＥ）含量降低，全血粘度升高。直线相关分析，ＰＣ与全血高切粘度呈负相关，神经鞘磷脂（ＳＭ）与全血低切粘度呈正相关。结论脑梗塞患者红细胞膜不仅存在胆固醇代谢异常，同时也存在磷脂组分代谢障碍，后者对血粘度产生影响。
Objective To investigate the changes of lipid components of erythrocyte membrane in patients with cerebral infarction and its relationship with blood viscosity. Methods The erythrocyte membrane lipid components and whole blood viscosity of 58 patients with cerebral infarction and 26 healthy people were measured. Results The level of erythrocyte membrane cholesterol (CHO) increased, the content of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) decreased, and the whole blood viscosity increased. Linear correlation analysis showed that PC was negatively correlated with the viscosity of whole blood high shear, and that SM was positively correlated with low shear viscosity of whole blood. Conclusion The erythrocyte membrane in patients with cerebral infarction has not only the abnormal metabolism of cholesterol, but also the metabolic disorder of phospholipid components, which have an impact on the blood viscosity.