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为了说明药物作用的始动机制,1878年英国生理学家 Largley 在研究阿托品和毛果云香碱对猫唾液腺分泌的拮抗作用时,提出了在腺细胞上存在一种“接受物质”。1905年他在研究箭毒对抗菸碱的骨骼肌收缩作用中更肯定了以前的想法。1909年(Ehvlich)在
To illustrate the mechanism of initiation of drug action, British physiologist Largley proposed in 1878 to study the antagonism of atropine and pilocarpine on cat salivary gland secretion, suggesting the presence of a “receptor” on glandular cells. In 1905 he was more affirmed the previous idea in the study of contractile effects of arrowheads against nicotine in skeletal muscle. 1909 (Ehvlich)