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环氧合酶-2(COX-2)在Barrett化生-异型增生-腺癌序列中表达增高,可能是参与食管腺癌(EAC)癌变过程的重要因素。多数研究认为COX-2表达上调主要作用于癌变的早期阶段,并可能与酸和胆汁反流及其相关慢性炎症反应有关。COX-2 CA单倍型以及-765C、-1195A、8473 C等位基因可能是EAC易感性的遗传标记。COX-2表达水平可能作为EAC预后评估或预测放化疗敏感性的指标。COX-2抑制剂能否成为EAC化学预防的有效手段尚存在争议。
Cyclooxygenase-2 (COX-2) is expressed in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence, which may be an important factor in the carcinogenesis of esophageal adenocarcinoma (EAC). Most studies suggest that COX-2 upregulation plays a role in the early stages of carcinogenesis and may be related to acid and bile reflux and their associated chronic inflammatory responses. The COX-2 CA haplotype and -765C, -1195A, 8473C alleles may be genetic markers of EAC susceptibility. The expression level of COX-2 may be used as an index to evaluate the prognosis of EAC or to predict the sensitivity of chemoradiotherapy. Whether COX-2 inhibitors can be an effective means of chemical prevention of EAC remains controversial.