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目的:评估每日小剂量口服他达拉非治疗无性生活勃起功能障碍(ED-NS)患者的疗效。方法:2011年4月至2012年2月门诊符合ED-NS定义患者35例,年龄17～35(25.9±3.9)岁,每日口服他达拉非5 mg治疗3个月,治疗后停药随访3个月。采用北京大学第一医院男科中心设计的SIEF-NS,对患者治疗前、治疗后及随访3个月后SIEF-NS积分进行评估。结果:ED-NS患者治疗前SIEF-NS积分14～38(21.2±5.9)分,治疗3个月后SIEF-NS积分28～55(43.2±7.1)分,随访3个月后SIEF-NS积分26～56(42.1±7.4)分,治疗3个月后及随访3个月后SIEF-NS积分之间无统计学差异,但与治疗前相比明显增加(P<0.05)。结论:每日小剂量口服他达拉非治疗ED-NS患者能够明显改善患者勃起功能,是治疗ED-NS患者的较好选择。
PURPOSE: To evaluate the efficacy of daily low-dose tadalafil in the treatment of ED-NS. METHODS: From April 2011 to February 2012, 35 outpatients with ED-NS definitions were defined, aged from 17 to 35 (25.9 ± 3.9) years. Tadalafil 5 mg daily was given for 3 months and discontinued after treatment Follow up for 3 months. Using SIEF-NS designed by the First Affiliated Hospital of Peking University, SIEF-NS scores were evaluated before treatment, after treatment and after 3 months of follow-up. Results: The SIEF-NS score of 14 -38 (21.2 ± 5.9) points before treatment in ED-NS patients was 28-55 (43.2 ± 7.1) after 3 months of treatment. After 3 months of follow-up, SIEF-NS score There were no significant differences in SIEF-NS scores between the two groups at 26-56 (42.1 ± 7.4) points after treatment for 3 months and 3 months after follow-up. However, SIEF-NS scores were significantly higher than those before treatment (P <0.05). Conclusion: Small daily oral dose of tadalafil in patients with ED-NS can significantly improve erectile function in patients with ED-NS is a better choice.