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γ氨基丁酸（ＧＡＢＡ）受体的反应动力学（激活、失敏和失活）是否在快速抑制性突触传递中起作用及怎样发挥作用是一个重要问题。随着分子生物学的发展、膜片钳技术及快速施药系统的应用，对ＧＡＢＡ受体的反应动力学的结构基础、单通道水平的发生机制及其功能意义等开始形成较全面的认识，揭示了其反应动力学在调节抑制性突触后电流（ＩＰＳＣ）中的关键作用及在快速抑制性突触传递中的重要意义。
It is an important question whether the kinetics (activation, desensitization and inactivation) of γ-aminobutyric acid (GABA) receptors play a role in the rapid inhibitory synaptic transmission and how it works. With the development of molecular biology, the patch-clamp technique and the application of rapid application system, the structural basis of the reaction kinetics of GABA receptor, the mechanism of single-channel level and its functional significance began to form a more comprehensive understanding, Revealed the key role of its reaction kinetics in regulating inhibitory postsynaptic currents (IPSCs) and its importance in rapidly inhibiting synaptic transmission.