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目的:探讨丹参注射液对肝性脑病(hepatic encephalopathy,HE)的防治作用及其作用的初步机制。方法:通过急性氨中毒动物模型和四氯化碳(CCl4)致肝损伤合并硫代乙酰胺(TAA)诱导髙血氨的大鼠肝性脑病模型,对氨中毒死亡时相、血氨、脑氨水平、肝脏功能以及肝脏病理组织学改变等指标进行了评价。结果:在急性氨中毒实验中,丹参注射液能使急性氨中毒小鼠存活时间明显延长;在CCL4和TAA诱导的肝性脑病大鼠模型中,丹参注射液能明显降低肝性脑病大鼠血氨和脑氨水平,并可在一定程度上降低肝性脑病大鼠血清ALT、AST、ALP、总胆红素(Tbil)含量,改善肝功能,从而防治肝性脑病。结论:丹参注射液对肝性脑病有较好的防治作用,可能与降低血氨和脑氨水平有关。
Objective: To explore the preventive and therapeutic effects of Danshen injection on hepatic encephalopathy (HE) and its primary mechanism. Methods: Rat model of hepatic encephalopathy was induced by acute ammonia poisoning animal model and carbon tetrachloride (CCl4) -induced hepatic injury combined with thioacetamide (TAA). The effects of ammonia poisoning on death phase, blood ammonia, brain Ammonia levels, liver function and histopathological changes of liver indicators were evaluated. Results: In the experiment of acute ammonia poisoning, Salvia miltiorrhiza injection could prolong the survival time of acute ammonia poisoning mice. In CCL4 and TAA-induced rat model of hepatic encephalopathy, Salvia miltiorrhiza injection can significantly reduce the blood of rats with hepatic encephalopathy Ammonia and brain ammonia levels, and to a certain extent reduce hepatic encephalopathy rat serum ALT, AST, ALP, total bilirubin (Tbil) content, improve liver function, and thus prevention and treatment of hepatic encephalopathy. Conclusion: Salvia miltiorrhiza injection has a good preventive and therapeutic effect on hepatic encephalopathy, which may be related to the reduction of blood ammonia and brain ammonia levels.