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食管癌细胞在体外用SD大鼠视网膜为其侵袭靶子,经扫描电镜、透视电镜观察,显示了肿瘤细胞借助其丝状伪足粘附于内界膜上,进一步向下侵袭视网膜深层。对照组用巨噬细胞、纤维母细胞和直径9.28μm的胶粒分别种植在视网膜上均不见上述改变。此外,又将6株人肺癌细胞分别注射于裸鼠眼玻璃体房内,在注射后第15天、30天取出眼球,制片经光镜观察,结果发现在体外实验表现出高移动性、高粘连性的肺巨细胞癌在体内对视网膜侵袭力最强,为6株肺癌之冠;相反,体外实验表现低移动性、低粘连性的一株肺癌腺在体内对视网膜的侵袭力亦最低。体内、体外实验结果基本一致。证明视网膜既可以用于体内又可以用于体外实验,它是用来作为研究肿瘤侵袭行为理想的实验模型。
Esophageal cancer cells in vitro using the SD rat retina as its target of invasion, by scanning electron microscopy, electron microscopy, showing tumor cells with its filopodia to adhere to the inner limiting membrane, and further down the invasion of the retina. The control group with macrophages, fibroblasts and 9.28 μ m diameter particles were implanted in the retina were not seen the above changes. In addition, 6 human lung cancer cells were injected into the vitreous chamber of nude mouse eyes respectively. The eyeballs were taken out on the 15th day and the 30th day after injection. The light microscope observation showed that the in vitro experiments showed high mobility and high Adhesive pulmonary giant cell carcinoma in the body of the strongest invasion of the retina, the highest of 6 lung cancer; the contrary, in vitro experiments showed low mobility, low adhesion of a lung adenocarcinoma in the body of the invasion of the retina is also the lowest. In vivo, in vitro experimental results are basically the same. Demonstrating that the retina can be used both in vivo and in vitro, it is used as an experimental model for studying the aggressive behavior of tumors.