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支气管哮喘(以下简称哮喘)的发病机理目前尚不完全清楚。IgE增高引起Ⅰ型变态反应在发病中的重要地位已经得到公认。自从1966年发现IgE以来,各国学者对B淋巴细胞合成IgE的调控机制曾作了大量的研究。动物实验证明IgE的增高受胸腺依赖淋巴细胞(T细胞)的调节,而且IgE的产生更受T辅助细胞和T抑制细胞的调节影响。近年来,随着单克隆抗体技术的应用,国外对哮喘病人的T淋巴细胞及其功能作了一系列研究,本文对这方面的进展作一综述。
The pathogenesis of bronchial asthma (hereinafter referred to as asthma) is not yet fully understood. IgE increased type Ⅰ induced allergy in the pathogenesis of the important position has been recognized. Since the discovery of IgE in 1966, scholars from various countries have done a lot of research on the regulatory mechanism of IgE synthesis by B lymphocytes. Animal experiments show that the increase of IgE is regulated by thymus dependent lymphocytes (T cells), and the production of IgE is more affected by the regulation of T helper cells and T suppressor cells. In recent years, with the application of monoclonal antibody technology, foreign countries conducted a series of studies on T lymphocytes and their functions in asthmatic patients. This article reviews the progress in this field.