论文部分内容阅读
本文采用D—氨基半乳糖形成的急性肝功能衰竭模型大鼠,观察云芝胞内多糖-Ⅱ注射剂对肝损害病变过程的影响。 结果表明注射该药物(50mg/d连续 3天)后,印度墨汁清除率K值在健康动物有明显提高(0.0393 ± 0.0086比注射前0.0259±0.0055,P<0.005)。在D—氨基半乳糖形成的肝损害大鼠K值也有明显提高(0.0227±0.0049增高到0.0359±0.00624,P<0.001),而在对照组K值虽亦有所增高,但在统计学上未见明显差异(P>0.05)。说明该品能使RES功能增强。实验组的SGPT与对照比较有明显减轻(SGPT 342±313比690±296μ/dl,p<0.005),存活率有明显提高(8/12只即66.7％比1/12只即8.3％,p<0.01)。结果证明该产品可增强RES功能,使D-氨基半乳糖诱致肝损害减轻和存活率明显增高。其作用机制或与内毒素血症的明显改善有关。
In this paper, D-galactosamine-induced acute liver failure rats were used to observe the effect of polysaccharide-Ⅱ injection of Coriolus versicolor on the lesion of liver damage. The results showed that after the injection of the drug (50mg / d for 3 consecutive days), the value of Indian ink clearance K was significantly higher in healthy animals (0.0393 ± 0.0086 than before 0.0259 ± 0.0055, P <0.005). The K value of liver injury in D-galactosamine group was also significantly increased (0.0227 ± 0.0049 to 0.0359 ± 0.00624, P <0.001), while in the control group K values were also increased, but not statistically See significant difference (P> 0.05). Description of the goods make RES function enhanced. The SGPT of the experimental group was significantly reduced compared with the control group (SGPT 342 ± 313 vs 690 ± 296μ / dl, p <0.005), and the survival rate was significantly increased (8/12, ie, 66.7% vs 1/12, ie 8.3%, p <0.01). The results show that the product can enhance the RES function, so that D-galactosamine induced liver damage and significantly reduce the survival rate. Its mechanism of action or with endotoxemia significantly improved.