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长时间暴露于高浓度氧中可引起所谓“氧中毒”的急性肺损害,以肺泡最为严重,其损害程度取决于氧浓度与暴露时间。已有研究提示,吸100％纯氧至少在24小时内是安全的,但也发现伴有下呼吸道暂时的机能异常;吸高浓度氧2～3天则可能产生肺组织结构的永久性损害。本文通过人体试验进一步阐明了氧对肺的毒性及作用机理。 16名(男10女6)健康志愿者分别接受二阶段试验。空气阶段:在普通空气房间自由呼吸2周。氧气阶段:用浓度至少95％的氧气密闭面罩呼吸,直至出现症状。10例先空气阶段后氧气阶段;4例先氧气阶段后空气阶段,以观察恢复情况;2例在氧气阶段用
Prolonged exposure to high levels of oxygen can cause so-called “oxygenated” acute lung injury, with the most severe alveoli, the degree of damage depending on oxygen concentration and exposure time. Studies have shown that 100% pure oxygen inhalation is safe for at least 24 hours, but also found to be accompanied by temporary dysfunction of the lower respiratory tract; high concentrations of oxygen 2 to 3 days may cause permanent damage to the lung tissue structure. This paper further elucidates the toxicity and mechanism of oxygen to the lung through human test. Sixteen (male 10 female 6) healthy volunteers were enrolled in a two-phase trial. Air stage: Free air in normal air room for 2 weeks. Oxygen Stage: Breathe with an oxygen-masked mask at a concentration of at least 95% until symptoms appear. 10 cases of air phase after the first oxygen stage; 4 cases of oxygen stage after the first phase of the air to observe the recovery; 2 cases in the oxygen phase