本文研制了东莨菪碱透皮控释膜剂。采用自行设计的体外扩散装置,分别研究了药库、含药压敏胶和复合膜等各层次及控释膜剂的体外释药速率,该制剂在最初4h释放初始剂量约200μg。达到稳态释放阶段后(4～72h),由控释膜控制其释药速率为2.8μg/cm~2·h。用大鼠离体皮肤研究渗透速率,药物以零级速率经皮渗透,0～12h内渗透速率为3.52μg/cm~2·h。 In this paper, scopolamine transdermal controlled release film was developed. The self-designed in vitro diffusion devices were used to study the in vitro drug release rates of drug depots, drug-containing pressure-sensitive adhesives and composite membranes, and the release of controlled-release film respectively. The initial release dose of this preparation was about 200 μg in the first 4 hours. After reaching the steady-state release phase (4 ~ 72h), controlled release membrane controlled release rate of 2.8μg / cm ~ 2 · h. Penetration rate was studied in isolated rat skin, and the drug permeated through the skin at 0th order rate. The permeation rate was 3.52μg / cm ~ 2 · h within 0-12h.