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目的研究外阴尖锐湿疣患者宫颈高危型人乳头瘤病毒的感染情况,探讨对这部分人群进行宫颈高危型HPV检测的必要性和意义。方法用第二代基因杂交捕获技术检测142例外阴尖锐湿疣女性患者及212例健康女性宫颈高危型人乳头瘤病毒,比较二组宫颈高危型人乳头瘤病毒阳性率及病毒载量。结果尖锐湿疣组和健康对照组高危型人乳头瘤病毒阳性率分别为54.2%(77/142)和13.2%(28/212),二组阳性率差异有统计学意义(P<0.05)。尖锐湿疣组病毒载量1~24例,10~16例,100~22例,≥1000 15例。健康对照组病毒载量1~10例,10~10例,100~7例,≥1 000 1例,尖锐湿疣组病毒载量≥1 000者与对照组比较差异有统计学意义(P<0.05)。结论外阴尖锐湿疣患者宫颈HR-HPV阳性率和高病毒载量者较普通人群显著增高,应重视尖锐湿疣患者宫颈HR-HPV的检测。
Objective To study the infection of high risk human papillomavirus (HPV) in patients with vulvar genital warts, and to explore the necessity and significance of HPV detection in this population. Methods Two hundred and seventy-two cases of genital warts and 212 healthy women with high-risk HPV genotypes were detected by the second generation hybridization capture technique. The positive rate and viral load of high-risk HPV were compared between the two groups. Results The positive rates of high risk HPV were 54.2% (77/142) and 13.2% (28/212) in genital warts and healthy controls, respectively. The positive rates of the two groups were statistically significant (P <0.05). Condyloma acuminatum group viral load of 1 to 24 cases, 10 to 16 cases, 100 to 22 cases, ≥ 1000 15 cases. In the healthy control group, the viral load was 1 to 10 cases, 10 to 10 cases, 100 to 7 cases, ≥1 000 cases, the genital warts group viral load≥1 000, the difference was statistically significant (P <0.05 ). Conclusions Cervical HR-HPV positive rate and high viral load in patients with vulvar genital warts are significantly higher than those in the general population. HR-HPV detection in patients with condyloma acuminatum should be emphasized.