论文部分内容阅读
目的研究婴儿初次接种麻疹减毒活疫苗(MV)的免疫成功率、抗体几何平均滴度(GMT)与婴儿月龄的关系。方法全面收集同时进行MV 6月龄、8月龄初次免疫并报告了相应免疫成功率、抗体GMT的文献,运用RevMan软件对免疫成功率、抗体GMT进行Meta分析;并对免疫成功率进行敏感性分析。结果共有10篇文献符合纳入标准,8月龄与6月龄初免成功率差值d-=0.06,其95%可信区间(0.03~0.10),8月龄、6月龄抗体GMT的平均数分别为1∶1 539.17、1∶909.60,GMT的比值为1.77(1.13~2.75);免疫成功率的敏感性分析,Z=2.78,P=0.005,不改变原分析结果的性质。结论8月龄接种MV免疫成功率及抗体GMT均可超过6月龄接种,宜采取继续以8月龄为MV初次免疫月龄及开展强化免疫、做好常规免疫的策略来消除麻疹。
Objective To study the immunization success rate, the geometric mean antibody titer (GMT) and the age of infants on infants immunized with live attenuated measles vaccine (MV). Methods A comprehensive collection of 6-month-old and 8-month-old immunized rabbits with the first immunization and reported the corresponding success rate of immunization and antibody GMT was performed. The RevMan software was used to analyze the success rate of immunization and antibody GMT. The sensitivity of immunization success rate analysis. Results A total of 10 articles met the inclusion criteria. The difference in success rate of initial immunization between 8 months and 6 months was d- = 0.06. The 95% confidence interval (0.03-0.10), the mean of GMT at 8 months and 6 months The ratios of 1: 539.17,1:909.60 and GMT were 1.77 (1.13-2.75) respectively. The sensitivity analysis of immunity success rate was Z = 2.78, P = 0.005, which did not change the nature of the original analysis results. Conclusion The success rate of immunization at 8 months of age and the antibody GMT can be inoculated more than 6 months of age. It is advisable to adopt the strategy of continuing to take 8 months of age as the primary immunization month for immunization and carrying out intensive immunization and doing routine immunization to eliminate measles.