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Generation and characterization of a novel CYP3A1/2 double knockout rat model using CRISPR-Cas9 syst
[期刊论文] 作者：WANG Xin,LU Jian,SHAO Yan-jiao,
来源：中国药理学与毒理学杂志 年份：2016
OBJECTIVE Cytochrome P450(CYP)3A accounts for nearly 30%of total CYP enzymes in human liver and participates in the metabolism of over 50%of clinical drugs.CYP3...
Generation and characterization of a novel CYP3A1/2 double knockout rat model using CRISPR-Cas9 syst
[会议论文] 作者：LI Da-li,WANG Xin,LU Jian,SHAO Yan-jiao,QIN Xuan,LIU Dao-zhi,CHEN Ang,LIU Ming-yao,
来源：中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 年份：2016
OBJECTIVE Cytochrome P450 (CYP) 3A accounts for nearly 30% of total CYP enzymes in human liver and participates in the metabolism of over 50% of clinical dr...
Generation and characterization of a novel CYP3A1/2 double knockout rat model using CRISPR-Cas9 syst
[期刊论文] 作者：WANG Xin,LU Jian,SHAO Yan-jiao,QIN Xuan,LIU Dao-zhi,CHEN Ang,LI Da-li,LIU Ming-yao,,
来源：中国药理学与毒理学杂志 年份：2016
OBJECTIVE Cytochrome P450(CYP)3A accounts for nearly 30%of total CYP enzymes in human liver and participates in the metabolism of over 50%of clinical drugs.CYP3...
Generation and characterization of a novel CYP3A1/2 double knockout rat model using CRISPR-Cas9 syst
[会议论文] 作者：WANG Xin,LU Jian,SHAO Yan-jiao,QIN Xuan,LIU Dao-zhi,CHEN Ang,LI Da-li,LIU Ming-yao,
来源：中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 年份：2016
OBJECTIVE Cytochrome P450 (CYP) 3A accounts for nearly 30% of total CYP enzymes in human liver and participates in the metabolism of over 50% of clinical drugs.CYP3A also plays an important role in th...
[会议论文] 作者：Li Da-li,Lu Xiao-ling,Zhao Yong-xiang,Liu Ming-yao,Qiu Zhong-wei,Shao Yan-jiao,Chen Yu-ting,Guan Yu-ting,
来源：华东地区第13届实验动物科学学术交流会 年份：2014
The CRISPR-Cas system has been developed as an efficient gene editing technology in cells and model organisms.Here we demonstrated that the CRISPR-Cas system induced genomic DNA fragment deletion in m...
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