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Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Mon
[期刊论文] 作者:Shihao Wu,Xia Ma,Xiao Li,Tianlin Cheng,Zhifang Chen,Jing Wu,Longbao Lv,Ling Li,Liqi Xu,Wenchao Wang,Yingzhou Hu,
来源:神经科学通报(英文版) 年份:2021
Whether direct manipulation of Parkinson\'s disease (PD) risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue.Here,we used an adeno-associated virus serotype 9(AAV9)-delivered CRISPR/Cas9 system......
Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaq
[期刊论文] 作者:Shouzhen Li,Yingzhou Hu,Yunqin Li,Min Hu,Wenchao Wang,Yuqian Ma,Yuan Cai,Min Wei,Yichuan Yao,Yun Wang,
来源:科学通报(英文版) 年份:2021
Retinitis pigmentosa (RP) is a form of inherited retinal degenerative diseases that ultimately involves the macula,which is present in primates but not in the r...
[期刊论文] 作者:Li,Ling-Yan Su,Lixin Yang,Min Li,Qianjin Liu,Zhenhui Li,Yan Hu,Hongwei Li,Shihao Wu,Wenchao Wang,Yingzhou Hu,
来源:国家科学评论(英文版) 年份:2021
Evidence for the existence of mon-keys with spontaneous Parkinson's disease(PD)has been lacking.Here,we screened macaque colonies at the Kunming Primate Researc...
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