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Morphological characteristics of skulls in tissue-specific gain-of-function mutation of FGFR2+/P253R
[会议论文] 作者：Fengtao Luo,Xiaolan Du,Lin Chen,
来源：3rd International Conference on Fibroblast Growth Factors (F 年份：2012
Fgfr2+/P253R mouse model mimicking human Apert syndromes (AS) showed precocious closure of coronal sutures, premature of cranial base and dysmorphology of brain.Thus, abnormality in sutures, cranial b...
[会议论文] 作者：Nan Su,Rui Zhou,Siyu Chen,Can Li,Xiaolan Du,Lin Chen,
来源：3rd International Conference on Fibroblast Growth Factors (F 年份：2012
Fibroblast growth factor receptors 3 (FGFR3) is one of a family of 4 membrane bound receptor tyrosine kinases (FGFR1-4).FGFR3 is a negative regulator of bone development.The gain-of-function mutationo...
Exogenous PTH1-34 can rescue the delayed fracture healing caused by gain-of function mutation of FGF
[会议论文] 作者：yangli xie,siru zhou,wei xu,zuqiang wang,junlan huang,xiaolan du,lin chen,
来源：中华医学会第八次全国骨质疏松和骨矿盐疾病学术会议 年份：2015
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Exogenous PTH1-34 can rescue the delayed fracture healing caused by gain-of function mutation of FGF
[会议论文] 作者：yangli xie,siru zhou,wei xu,zuqiang wang,junlan huang,xiaolan du,lin chen,
来源：中华医学会第八次全国骨质疏松和骨矿盐疾病学术会议 年份：2015
Achondroplasia (ACH) is the most common form of dwarfism caused by activated mutations of FGFR3 gene.Gain-of-function mutation of FGFR3 in mice (FGFR3G369C/+ mice,ACH mice) resulted in delayed fractur...
[期刊论文] 作者：Zhenhong Ni,Siru Zhou,Song Li,Liang Kuang,Hangang Chen,Xiaoqing Luo,Junjie Ouyang,Mei He,Xiaolan Du,Lin,
来源：骨研究（英文版） 年份：2020
INTRODUCTIONrnOsteoarthritis (OA) is a highly prevalent type of degenerative joint disease that affects over 300 million people worldwide.1 Chronic pain and mot...
[会议论文] 作者：,Ying Zhu,Lin Chen,Hubing Qi,Qiaoyan Tan,Lin Chen,Huabing Qi,Zixian Lei,Xiaofeng Wang,Yaqi Duan,Xiaolan Du,
来源：3rd International Conference on Fibroblast Growth Factors (F 年份：2012
Multiple constitutively active mutations of FGFR3 can lead to achondroplasia (ACH), one of the most common dwarfisms in humans, but the molecular mechanism remains elusive.In this study, we found that...
[期刊论文] 作者：Jing Yang,Can Li,Bo Chen,Xianding Sun,Liang Kuang,Wanling Jiang,Zhenhong Ni,Quan Wang,Shuai Chen,Xiaolan Du,
来源：骨研究（英文版） 年份：2022
INTRODUCTIONrnLow back pain (LBP) is a debilitating condition that affects～84％of the population in their lifetime.1 LBP affects physical function, reduces quality of life, and causes psychological distress.2 Although LBP is a multifactorial d......
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