Exogenous PTH1-34 can rescue the delayed fracture healing caused by gain-of function mutation of FGF

来源 :中华医学会第八次全国骨质疏松和骨矿盐疾病学术会议 | 被引量 : 0次 | 上传用户:liuhu986
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Achondroplasia (ACH) is the most common form of dwarfism caused by activated mutations of FGFR3 gene.Gain-of-function mutation of FGFR3 in mice (FGFR3G369C/+ mice,ACH mice) resulted in delayed fracture healing by inhibiting chondrocyte differentiation and bone resorption.The expression of PTHrP in callus is lower in ACH.Researches have demonstrated that PTH1-34 preferentially enhanced chondrocyte recruitment the rate of chondrocyte maturation to stimulate endochondral ossification.
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