Checkpoint相关论文
Phosphorylation of CtIP by PI3KK is important for endresection,but dispensable for B cell developmen
Objective Three major pathways exist for the repair of DNA double-stranded breaks(DSBs)in mammalian cells: non-homologou......
An engineered PD-1-based and MMP-2/9-oriented fusion protein exerts potent antitumor efficacy agains
Recent studies have shown that PD-1/PD-L1 checkpoint blockade is a dramatic therapy for melanoma through enhancing antit......
The breakthrough of immune checkpoint inhibitor(ICI)therapy has created extensive opportunities for cancer immunotherapy......
Efficacy of artificial liver support system in severe immuneassociated hepatitis caused by camrelizu
BACKGROUND Immune checkpoint inhibitors(ICIs)can lead to immune-related hepatitis(IRH)and severe liver damage,which is l......
Pancreatic cancer, a highly lethal cancer, has the lowest 5-year survival rate forseveral reasons, including its tendenc......
Atezolizumab-induced anaphylactic shock in a patient with hepatocellular carcinoma undergoing immuno
BACKGROUND Atezolizumab is a programmed death ligand 1(PD-L1)inhibitor,and its combination with bevacizumab has been pro......
Combined immune checkpoint inhibitors of CTLA4 and PD-1 for hepatic melanoma of unknown primary orig
BACKGROUND Melanoma is uncommonly found in lymph nodes,subcutaneous tissue,or visceral organs without a primary lesion,w......
Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel
Immune checkpoint inhibitors(ICI)have markedly changed the landscape of cancer therapy.By re-invigorating the immune sys......
Immunotherapy has been recently considered as a promising alternative for cancer treatment.Indeed,targeting of immune ch......
This review focuses on the development of hyperglycemia arising from widely used cancer therapies spanning four drug cla......
Imaging diagnosis of bronchogenic carcinoma(the forgotten disease)during times of COVID-19 pandemic:
Patients with bronchogenic carcinoma comprise a high-risk group for coronavirus disease 2019(COVID-19),pneumonia and rel......
Programmed cell death protein 1(PD-1)is an immune checkpoint modulator and a major target of immunotherapy as anti-PD-1 ......
Hepatocellular carcinoma(HCC) is the most frequent primary liver cancer,leading to 74.6 thousand deaths annually.The pro......
Novel treatment modalities are necessary for pancreatic cancer. Immunotherapy with immune checkpoint inhibition has show......
AIM:To investigate the expression of tumor suppressorgene p53 and spindle checkpoint gene Mad2,and todemonstrate their ......
AIM:To understand the effect of low concentration of N-methyl-N′-nitro-nitrosoguanidine (MNNG),which is a widelydistri......
With the increasing impact of software systems on everyone’s daily work and life,it is becoming increasingly important ......
AIM:To investigate the expression of tumor suppressorgene p27 and spindle checkpoint gene Mad2 and todemonstrate their ......
Elevated level of spindle checkprotein MAD2 correlates with cellular mitotic arrest,but not with ane
AIM:To study the relevance of spindle assembly checkprotein MAD2 to cellular mitotic status,aneuploidy and other clinico......
Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human c
AIM: To investigate whether 7-hydroxystaurosporine (UCN-01) affects cell cycle progression in arabinosylcytosine (ara-C......
多态性蛋白Mad2 折叠与功能的研究摘要：Mad2 是纺锤体检查点(Spindle Assembly Checkpoint,SAC)的关键蛋白,在有丝分裂过程中能......
该文研究的主要内容Checkpoint的设置是BIST软件可测性设计中的一个重要模块.Checkpoint的设置类似于硬件BIST技术中预埋测试电路......
随着并行计算的规模越来越大,超级计算机的规模扩展到成千上万的独立节点,这意味着硬件更容易在运行时间较长的任务时发生故障,已......
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MitoticcheckpointgenehsMAD2expressiondecreasesinacuteleukemiaZHANGXiaoHui1, HUANGGaoSheng1, LIANGYi......
期刊
恢复是实现容错系统容错目的和提高系统可用性的重要环节。基于自行研制的TMR容错服务器系统 ,提出了一种以检查点为基础的进程复......
Evaluation of response to immune checkpoint inhibitors: Is there a role for positron emission tomogr
Strategies targeting intracellular negative regulators such as immune checkpoint inhibitors(ICPIs) have demonstrated sig......
To treat many types of cancer, ionizing radiation (IR) is primarily used as external‐beam radiotherapy, brachytherapy, ......
新型非易失存储器提供了高访问速度,大容量,字节访问粒度,以及非易失等特性。这些特性将为容错带来新的机遇。本文提出了基于非易......
Network of workstations (NOW) now becomes one of the main trends of parallel computing. But for long-running scientific ......
我从事外语教学工作十多年了,在教学过程中,每届都碰到了一定数量的外语学习上的差生。怎样做好差生的转化工作,是每个教师必须认......
SYN proxy is a firewall’s solution to protect against SYN flooding. It plays well under the low rate of attacks, but st......
Study the technology of grid middleware based on P-S, and illustrates the interrelated-technical question in details, su......
目的探讨细胞周期G1调控点(checkpoint)相关调节因子细胞周期素D1(CyclinD1)、周期素依赖性蛋白激酶4(CDK4)、多重肿瘤抑制因子(P1......
Wide-area systems are becoming a popular infrastructure for long-running applications. Rollback- recovery, as a common t......
Ataxia telangiectasia-mutated-Rad3-related DNA damage checkpoint signaling pathway triggered by hepa
AIM: To explore whether acute cellular DNA damage response is induced upon hepatitis B virus (HBV) infection and the eff......
AIM: To investigate whether hepatitis B virus (HBV) infection activates DNA damage response and DNA repair cofactors inh......
BACKGROUND:There are more than 100 million asymptomatic HBV carriers(ASCs)in China and they are at a high risk of develo......
An Optimistic Checkpoint Mechanism Based on Job Characteristics and Resource Availability for Dynami
In the paper,based on the job characteristics and resources availability,an optimistic checkpoint mechanism for dynamic ......
Necessary and sufficient checkpoint selection for temporal verification of high-confidence cloud wor
On-time completion is an important temporal Qo S(Quality of Service) dimension and one of the fundamental requirements f......
Hepatitis B virus(HBV) infection has received increasing public attention. h BV is the prototypical member of hepadnavir......
Inhibition of histone deacetylase for the treatment of biliary tract cancer:A new effective pharmaco
AIM:TO investigate in vitro and in vivo therapeutic effects of histone deacetylase inhibitors NVP-LAQ824 and NVP-LBH589 ......
Q:最近我看到一个IT方面的新闻,上面说有一个全新的恶意程序,入侵了超过100万的谷歌账号,而且这个数字每天都在快速地增加。那么通......
Objective To assess the ability of tetrandrine (Tet) to enhance the sensitivity to irradiation and its mechanism in cell......
The emergence of the “precision-medicine” paradigm in oncology has ushered in tremendous improvements in patient outco......
Pancreatic ductal adenocarcinoma(PDAC) is an almost uniformly lethal disease with less than 5% survival at five years. T......
Objective To evaluate the effect of dynein inhibitor on mouse oocyte in vitro maturation and its cyclin B1 transcriptio......
Nitric oxide (NO) as an immunoregulatory molecule,predominantly depending on S-nitrosylation,acts as a versatile player ......
