HEDGEHOG相关论文
我们前期发现PRR11（proline-rich protein 11）与SKA2（spindle and kinetochore associated complex subunit 2）构成“头对头”基因对,......
第一部分 Sufu基因条件性敲除小鼠的构建及验证[目的]构建LysM-Cre+/+;Sufufx/fx小鼠,验证该Cre在髓系细胞中敲除Sufu基因的效率,......
研究目的:探索Y-box结合蛋白1（YB-1）在肝祖细胞（HPC）介导的肝再生和肝纤维化中的作用及其机制。研究方法:采用免疫荧光和免疫组化技术......
目的:（1）探讨miR302/367簇在前列腺癌及雄激素非依赖性产生中的作用。（2）探讨Numb在前列腺癌中的功能和分子机制以及Numb-/low细胞群在......
前期研究表明,蛹虫草活性成分虫草素能有效抑制乳腺癌移植瘤的生长和转移,但其作用机制未清楚.本研究取三阴性乳腺癌移植瘤样品,通......
该研究旨在探讨肿瘤相关成纤维细胞(CAFs)对食管鳞状细胞癌(ESCC)细胞增殖的影响及抗癌生物活性肽(ACBP)对增殖的干预作用和可能的......
目的 制备胰腺癌靶向的碳纳米管超声造影剂(MWCNT-PEG-HH)并评价其体内外靶向性效果.方法 合成PEG化的多壁碳纳米管(MWCNT-PEG)并......
目的：以未成熟小鼠肋软骨细胞作为软骨细胞的来源，结合Col2a1-CreERT2；Ihhfl/fl基因工程小鼠，用周期性压缩应力(Flexcell5000施加正弦......
目的 Studies have demonstrated that Hedgehog signaling pathway is activated in human hepatocarcinoma,whether it is also ......
目的 探讨泛素连接酶UBR3 在果蝇眼睛发育过程的调控机制。方法 通过P 因子敲除及RNA 干扰构建泛素连接酶UBR3 缺失或表达下调的突......
Hedgehog(Hh)信号通路是一条高度保守的胚胎形成素信号通路，与成人组织、器官损伤修复过程密切相关。最近有大量的研究资料和实验数......
Hedgehog/Gli1 signal pathway promotes cell migration and invasion by inducing epithelial-to-mesenchy
Objective Activation of hedgehog(Hh)signaling pathway has been implicated in progression of a variety of tumors....
目的：探讨Hedgehog信号转导通路在皮肤鳞状细胞癌中的激活水平及抑制该信号通路对鳞癌细胞增殖的影响。方法：选取临床和病理确诊为SC......
目的探讨柠檬酸镧对肝癌细胞增殖、凋亡的影响及其可能的机制。方法分别使用不同浓度的环巴胺-KAAD以及柠檬酸镧处理人肝癌细胞株S......
目的 研究Hedgehog信号传导通路相关基因在肝癌组织中的表达,及其抑制剂对肿瘤细胞生长的影响.方法 免疫组化法检测14例肝癌组织切......
目的 探讨Patched-1、Gli-1在银屑病皮损中的表达.方法 应用免疫组化和原位杂交的方法,检测银屑病皮损及正常人皮肤中Patched-1、G......
OBJECTIVE To identify the inhibitory effect of ursolic acid on the colorectal cancer HCT116 cells in vitro and in vivo,a......
Inhibitory action of berberine on colorectal cancer HCT116 cells by regulation of Hedgehog signaling
OBJECTIVE To investigate the inhibition and mechanism of berberine on human colorectal cancer HCT116 cells through canon......
Hedgehog plays an important role in a wide range of physiological and pathological conditions.Paracrine activation of He......
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Background: Upon liver injury, quiescent hepatic stellate cells(q HSCs), reside in the perisinusoidal space, phenotypica......
Aberrantly activated Hedgehog(Hh)pathway is critical for driving the initiation and progression of multiple types of can......
The hedgehog signaling cascade is an evolutionarily conserved pathway that regulates multiple aspects of embryonic devel......
Identification of hedgehog signaling as a potential oncogenic driver in an aggressive subclass of hu
Hepatocellular carcinoma(HCC)is a heterogeneous disease and the second most common cause of cancer-related death worldwi......
Hedgehog信号通路是近年来抗肿瘤靶向治疗药物研究的一个新热点.本研究以4-(嘧啶-2-氨基)苯甲酰胺为母核,基于先导化合物1的构效关......
Medulloblastoma is the most common malignant pediatric brain tumor.Some are thought to originate from cerebellar granule......
In 1903, Farabee analyzed the heredity of the human digital malformation, brachydactyly, the first recorded disorder of ......
A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesiz......
刺猬的一生,通常既简单又平平无奇,住在一个箱子里,里面铺些毯子或者木屑,有一个转轮,或许还有一个卫生纸卷心。每天都有人给你喂......
Dear friends,do you like the hedgehog?Look at my picture.How lovely the hedgehogis!The hedgehog is only two years old.Bu......
目的探讨Runt-related transcription factor 2(Runx2)在Hedgehog促进成骨细胞晚期分化过程中的重要介导作用。方法培养MC3T3-E1细......
糖原合酶激酶-3(glycogen synthase kinase-3,GSK-3)是一种多功能的丝氨酸/苏氨酸蛋白激酶,在蛋白质合成、信号传递、细胞增殖、细......
目前,病人接受化疗后带来的脱发仍是一个令人烦恼的问题。治疗使许多病人感到极度心烦意乱,其中一些病人不愿意开始治疗,而其他一......
AIM: To investigate the role that the hedgehog (Hh)signaling pathway, which includes sonic hedgehog (Shh),Patched (Ptc),......
Hedgehog (HH)信号通路是经典的控制胚胎发育的信号传导途径,最近研究发现,该通路在肿瘤的发生和发展过程中发挥重要作用.HH信号对......
Hedgehog（ Hh）信号通路不仅在前列腺的胚胎发育和器官形成扮演重要的角色，而且在前列腺癌的肿瘤形成、侵袭、转移中起十分重要的作用......
脂肪组织在动物的能量代谢和免疫调节中起着重要的作用，当脂肪沉积过多，对人而言，将引发肥胖症、II型糖尿病和心血管疾病等多种疾病；对......
研究背景:非小细胞肺癌(non-small cell lung cancer,NSCLC)作为世界上发病率最高、死亡率最高的恶性肿瘤性疾病,尽管目前诊断、治......
椎间盘退变(IDD)是引发腰痛的首要原因,预防和早期治疗IDD是脊柱外科医师研究的重要方向。然而,IDD的发病机制目前仍未完全明确,以......
Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironmen
The Hedgehog(HH)signaling pathway plays important roles in gastrointestinal carcinogen-esis and the gastrointestinal tum......
目的 探讨白杨素对前列腺癌的作用及分子机制.方法 体外培养前列腺癌DU145细胞,CCK8法检测DU145细胞活性,球体形成实验检测细胞球......
背景:结直肠癌(Colorectal Cancer,CRC)是世界范围内最常见的癌症之一,其发病率和死亡率一直居高不下。近期有研究报道PI3K/AKT/mT......
It's spring. Some animals curl* their hair. Little hedgehog* asks Red Fox* to curl his hair , too. Soon, little hedgehog......
The Hedgehog signaling pathway plays a key role in embryonic development and organ formation. Sonic hedgehog signaling p......
