NMDA相关论文
钙/钙调蛋白依赖的蛋白激酶Ⅱ（Ca2+/calmodulin-dependent protein kinase Ⅱ,CaMKⅡ）在脑内兴奋性突触部位丰富表达。通过催化谷氨......
目的:NMDA （N-甲基-D-天冬氨酸）受体是离子型谷氨酸受体的一个亚型,在神经系统突触传导发挥重要的生理作用,也和一系列神经类疾病和......
焦虑症可表现出焦虑样行为，其发病机制错综复杂且受多方面因素的影响，一线药物治疗效果也不甚理想。近年来发现，在自闭症、阿尔茨海默......
该文探究二甲双胍(metformin,Met)对N-甲基D-天冬氨酸(N-methyl-D-aspartic acid,NMDA)诱导的HT22细胞损伤的神经保护作用.体外培......
N-甲基-D-天冬氨酸（NMDA）是动物体内存在的一种天然氨基酸衍生物,对神经和内分泌具有重要的调控作用。（目的）本实验以不同浓度NMDA为试......
抑郁症是高发性的精神情感障碍性疾病,对人类工作和生活危害极大,因此,对于抑郁症发病机制的研究及其相关药物的开发成为目前亟待......
Propofol attenuates the adhesion of tumor and endothelial cells via inhibiting glycolysis in human u
Objective Background: Propofol is one of the most commonly used intravenous anesthetics,and,propofol inhibits tumor cell......
我们之前的研究发现,多种刺激(如高钾溶液,谷氨酸以及电刺激)均可引起大鼠蓝斑神经元的胞体树突去甲肾上腺素分泌(somatodendritic......
Objective In our previous study,we had proposed that in the upper stream of the known ciliary neurotrophic factor (CNTF)......
NMDA 受体是中枢神经系统内的离子型谷氨酸受体,近年研究显示,该受体亦广泛分布于多种外周非神经组织,包括胰岛细胞。研究报道,NMD......
会议
Effects of memantine on amyloid oligomer-induced impairment of synapticplasticity in vitro and in vi
Soluble amyloid-β protein (Aβ) plays a central pathogenic role in Alzheimers disease (AD).Memantine, a low-affinity N-......
Real-time calcium imaging during NMDA induced membrane potential oscillations in lamprey spinal neur
NMDA-receptor dependent, TTX-resistant membrane potential oscillations are considered to be important for the operation ......
Bis(7)-tacrine has been shown to prevent glutamate-induced neuronal apoptosis by blocking NMDA receptors.However,the cha......
Improvement of depression-like behavior in rat by memantine prevents heroin seeking after withdrawal
Objectives The aim of the present study was to determine a role of memantine in heroin withdrawal-nduced depression-like......
目的 在细胞水平探讨组胺及其受体在NMDA诱发的神经元损伤中的作用及其机制.方法 采用原代新生大鼠皮层细胞培养的方法,以NMDA急性......
会议
Improvement of depression-like behavior in rats by memantine prevents heroin seeking after withdrawa
OBJECTIVE Depression is the key symptoms in anhedonia after heroin withdrawal and also is often the main cause for recur......
目的 研究玻璃体腔注射N-甲基-D-天冬氨酸(N-methyl-D-aspartate,NMDA)诱导视网膜双极细胞树突损伤的分子机制。方法 C57BL/6J 小......
目的 观察锌和叶酸联合补充对抑郁症的的影响并探讨其作用机制.方法 雄性SD 大鼠随机分为5组：对照组(C,9只)、模型组(M,12只)、帕罗......
目的:雄黄(realgar)为含砷矿物药.因不合理使用单味雄黄或其复方制剂引起药源性慢性砷中毒事件时有报道,其中不乏新生儿、少儿滥用......
Spatiotemporal specific regulation of synaptic morphology and function by GABA uptake underlies emer
GABA transporter 1 (GAT1) plays an important role in GABA reuptake from GABAergic synaptic cleft, which mainly distribut......
Overactivation of NMDA receptor is a key event in excitotoxicity that induces a sudden intracellular.Ca2+ elevation and ......
Effect of KA and NMDA lesion of the medial prefrontal cortex and dorsal hippocampus on the methamphe
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Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprote
Among the most powerful analgesics, morphine is widely used in clinic.However, they are potentially extremely addictive ......
为探讨Ifenprodil在帕金森病(Parkinsan′s disease,PD)中自噬抑制的缓解作用,采用体内和体外两部分实验对其机制进行研究。对6-OH......
期刊
Neuropeptide S Enhances Memory and Mitigates Memory Impairment Induced by MK801, Scopolamine or Aβ1-
A growing body of evidence suggests that the endogenous ligand of NPSR,NPS,could promote arousal and anxiolytic-like......
Genistein inhibits Aβ 25-35 induced synaptic toxicity and regulates CaMKⅡCREB signaling pathway in S
Synaptic failure is considered as the earliest phase of Alzheimers disease (AD) pathology.Many studies have examined......
BACKGROUND:Activated N-methyl-D-aspartate(NMDA) receptor is involved in the formation of chronic neuropathic pain,and it......
目的:研究芝麻素对NMDA所致原代培养小鼠皮层神经元损伤的保护作用及其机制。方法:体外培养原代皮层神经元;免疫荧光染色鉴定细胞......
In this work,a calculation method of chemical kinetics was established for labeling reaction of 99mTc-N-ethyl-N2S2-meman......
脑室周围白质软化(periventricular leukomalacia,PVL)是脑室周围未成熟白质的缺血性病变,以形成髓鞘的少突胶质细胞(oligodendroc......
目的:观察肾虚质大鼠生长发育情况和海马N-甲基-D-天冬氨酸(NMDA)受体表达,探讨脑功能与肾藏志理论相关性。方法:采用“猫吓鼠”经......
Effects of acute and chronic administration of MK-801 on c-Fos protein expression in mice brain regi
Objective To investigate the effects of acute and chronic administration of the non-competitive NMDA receptor antagonist......
目的:建立NMDA诱导原代培养皮层神经元兴奋毒损伤模型,探讨NMDA对NMDA受体过度活化诱导兴奋性神经毒的可能途径。方法:原代培养新......
目的以往体内实验研究表明,乙醇能够引起纹状体、伏隔核和大脑皮层等部位抗坏血酸(AA)的释放,一些药物参与调节乙醇引起的AA的释放......
目的探讨继发于单纯疱疹病毒(HSV)脑炎后的儿童抗N-甲基-D-天冬氨酸(NMDA)受体脑炎的临床特点,进一步提高对该病的认识。方法对201......
为了探讨慢性应激性抑郁样行为发生过程中海马胶质细胞释放的喹啉酸(quinolinic acid,QUIN)的作用,以及与谷氨酸(glutamic acid,Gl......
N-methyl-D-aspartate receptors(NMDARs) containing different GluN2 subunits play distinct roles in synaptic plasticity.Su......
Dual effects of 3,4-methylenedioxymethamphetamine (ecstasy) on survival and apoptosis of primary hip
BACKGROUND: 3, 4-methylenedioxymethamphetamine (MDMA, also known as “ecstasy”) hasbeen shown to exhibit neurotoxic ef......
应激与中枢谷氨酸神经系统,特别是NMDA(N-甲基-D-天冬氨酸)受体功能有关。本文就应激与NMDA受体关系进行较系统的综述。
Stress i......
学习与记忆是大脑极为重要的两种生理功能,它们两者是相互区别又相互联系的神经生物学过程。学习指的是从外界获取新知识的生物学......
新生儿缺氧缺血性脑病（HIE）是导致新生儿死亡及影响神经预后的严重疾病，发病机理较为复杂，目前难以找到有效的预防和治疗方法。大量临......
兴奋性氨基酸（excitatoryaminoacid,EAA）是人类脑组织中的主要神经递质，在中枢神经系统发育中起着重要作用。EAA参于中枢神经系统发育......
