RASAGILINE相关论文
目的:探索雷莎吉兰不对称合成的新方法。方法:以1-茚酮为原料,经“一锅法”与R-叔丁基亚磺酰胺生成亚胺,后用NaBH4还原,经柱分离得......
Bio-analytical method development and validation of Rasagiline by high performance liquid chromatogr
The most suitable bio-analytical method based on liquid-liquid extraction has been developed and validated for quantific......
It has been suggested that in patients with Parkinson’s disease (PD) metabolism of the MAO-B inhibitor selegiline to me......
Background: Antiparkinsonian pharmacotherapy represents one of the most important expenses related to Parkinson’s disea......
本文以1-茚酮为原料,先合成消旋体,然后经L-酒石酸拆分的方法合成(R)-N-丙炔基-1-氨基茚满(1,Rasagiline)。成本低廉,易于操作,适合工业化生......