Signalpathway相关论文
Objective: The mechanism of Yupingfeng Powder in the treatment of non-small cell lung cancer was analyzed by network pha......
Transcriptional and proteomic analysis reveal recombinant galectins of Haemonchus contortus down-reg
In this study,a combined proteomic and transcriptomic analysis was performed to understand the mechanisms underlying the......
Transcriptional and proteomic analysis reveal recombinant galectins of Haemonchus contortus down-reg
In this study,a combined proteomic and transcriptomic analysis was performed to understand the mechanisms underlying the......
Non-esterified fatty acids activate the ROS-p38-p53/Nrf2 signaling pathway to induce bovine hepatocy
A high plasma concentration of non-esterified fatty acids (NEFAs) is an important pathogenic factor that leads to ketosi......
Hsa_circ_0080145 affects cell proliferation and apoptosis of colorectal cancer via regulation of Akt
Objective Circular RNAs have been reported to regulate tumorigenesis and served as a tumor target.The functional role an......
Advanced glycation end products promote TNF-a expression in T lymphocyte via p38、JNK and NF-κB signa
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Staphylococcal enterotoxin C2(SEC2)causes rapid clonal expansion of lymphocytes and secretion of T cell growth factors,l......
OBJECTIVE To investigate the subtype(s)of α2-adrenoceptor(α2-AR)that mediated the sedation of mice.And demonstrate the......
Aim:Particulate matter(PM)now threaten our health.As important components of PM,black carbon(BC)and aged black carbon ma......
Cisplatin-based chemotherapy is the standard therapy used to many cancers.However, its efficacy is largely limited by th......
Ursolic acid inhibits IL-1β-induced release of IL-6 and IL-8 via suppression of AKT,ERK and NF-kappa
Ursolic acid(Ursolic acid,UA),a pentacyclic triterpenoid compound present in a wide variety of plant foods,is reported t......
The research of signal path in osteogenetic differentiation of human umbilical cord mesenchymal stem
It has been reported that human umbilical cord mesenchymal stem cells(hUCMSCs)have the potential to differentiate into o......
A new peptide precursor, termed Sj7170, was characterized from the venomous gland cDNA library of the scorpion Scorpiops......
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Ratiometric Fluorescence Imaging of Endogenous H2Sn Revealing its Signaling Pathway in Non-Alcoholic
Hydrogen polysulfides(H2Sn,n > 1)proved to be a crucial reactive sulfur species(RSS)as their key functions in different ......
葡萄膜炎是一类发病机制尚不完全清楚的致盲率较高的眼病。近年来，研究发现白细胞介素(IL)-23/IL-17通路在葡萄膜炎发生中起着重要......
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Lipopolysaccharide Stimulates Surfactant Protein-A in Human Renal Epithelial HK-2 Cells through Upre
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血管平滑肌细胞(vascular smooth muscle cell，VSMC)的增殖、迁移和表型转换是多种心血管疾病，尤其是主动脉疾病发生发展的核心环节......
目的利用基因芯片技术筛选脊柱结核患者椎间盘病灶组织中差异表达的环状RNA(circRNA)并分析其在脊柱结核发生发展中可能的分子作用......
[Objective] To screen the genes related to cleft palate induced by Retinoic acid (RA), laying foundation for the res......
目的研究胆道闭锁肝纤维化过程中Shh信号通路核转录因子Gli1/Gli2在肝上皮-间充质转化(epithelial mesenchymal transition，EMT)中......
胰腺导管腺癌在消化系统肿瘤中的发病率逐年上升，其恶性程度高，患者预后差，5年生存率不足8%。胰腺癌对放化疗不敏感，寻找新的药物治疗......
甲状腺滤泡上皮细胞基底膜上的碘离子转运体可参与并介导细胞内外碘离子流动。机体众多含碘组织中，仅甲状腺滤泡上皮细胞内胶体的碘......
Neuronal changes in the retinal ganglion cell layer following recombinant human interleukin-2 intrav
Intraperitoneal injection of recombinant human interleukin-2(rhIL-2)inhibits neuronal apoptosis in the chronic ocular hy......
目的在分子水平研究创伤后肘关节外源性挛缩的机制。方法建立新西兰兔创伤后膝关节外源性挛缩模型,左膝经手术导致关节内骨折,并以......
目的探讨钙调蛋白激酶Ⅱ(CaMKⅡ)和细胞外信号调节激酶(ERK)在孤独症谱系障碍发病中的作用。方法孕12.5 d Sprague-Dawley孕鼠腹腔......
反流性食管炎（ RE）是临床常见的食管黏膜炎性病变，其与食管下括约肌功能失调，胃液或混合肠液反流刺激等原因密切相关。但至今RE的机制......
力学刺激会影响细胞凋亡的发生,进而影响组织器官结构和功能的变化,从而在机体的生理病理过程中起到重要作用,与很多疾病的发生发......
在糖尿病条件下糖基化终末产物(AGEs)形成速率加快,引起足细胞损伤,进而参与糖尿病肾病(DN)的发生.AGEs形成于葡萄糖和蛋白的相互......
全髋关节置换术后最常见的并发症是由无菌性松动引起的假体周围骨溶解。在该病理过程中，磨损颗粒被巨噬细胞吞噬并激活巨噬细胞和诱......
头颈部鳞状细胞癌(HNSCC)在人体肿瘤中常见,有着极高的发病率和病死率,严重威胁着人类健康.随着分子医学、蛋白质组学和生物信息学......
目的 检测银屑病患者皮损中磷酸化表皮生长因子受体(p-EGFR)表达的改变,探讨其相关的临床意义.方法 入选寻常型银屑病患者64例(银......
目前为止，对于需要牙髓治疗的患牙仍然面临一个怎样保护牙髓活力而不进行根管治疗的挑战。第三期牙本质的形成为活髓保存提供了可能......
目的 探讨抑癌基因PTEN及P13K/Akt信号通路主要成员P13K、AKT在子宫内膜癌中的表达及相关性.方法 应用免疫组化SP方法检测PTEN,P13......
目的分析神经母细胞瘤(NB) SOX2和FoxM1表达特点，初步探讨PI3K/AKT信号通路对SOX2、FoxM1调控作用。方法收集重庆医科大学附属儿童......
慢性炎性反应与多种恶性肿瘤的发生密切相关,胃癌就是典型之一.肿瘤坏死因子α(TNF-α)在慢性炎性反应介导胃癌发生的过程中发挥了......
The Changes of Protein Kinase C Activity in Peripheral Blood Lymphocytes in the Patients with Obstru
The roles of protein kinase C (PKC) signal pathway in the pathogenesis of obstructive jaundice were studied. PKC from cy......
Identification of a key G-protein coupled receptor in mediating appressorium formation and fungal vi
Fungal G-protein coupled receptors (GPCRs) play essential roles in sensing environmental cues including host signals.The......
维 A 酸 X 受体（RXR）是配体依赖的核转录因子，在调节一系列生理病理过程中起重要作用。在分子水平上，RXR 与多个信号通路相互作用，调控......
mTOR是一种丝氨酸/苏氨酸蛋白激酶,不仅在正常细胞的生长增殖中起着极其重要的作用,而且与癌细胞的生长密切相关,是细胞生长、分化......
Mechanisms of hepatocellular carcinoma and challengesand opportunities for molecular targeted therap
The incidence and mortality of hepatocellular carcinoma（HCC） have fallen dramatically in China and elsewhereover the past ......
