high-throughputscreening相关论文
Suppression of cellular O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) can repress prolifera-tion and migration......
金属-β-内酰胺酶L1是锌离子依赖性酶,对β-内酰胺抗生素耐药性的发展有所贡献.作为可以恢复β-内酰胺类抗生素功效的金属-β-内酰......
离子通道是极具潜力的药物靶点.近年来,越来越多的新的离子通道靶标在疾病中被发现,比如:疼痛、心血管疾病以及神经系统疾病.尽管......
A luminescence-based cytotoxicity assay revealed 20-Deoxyingenol 3-angelate is a potent immunostimul
Objective As central effector lymphocytes of the innate immune system,natural killer(NK)cells can eliminate transformed ......
A novel accurate method of human protein tyrosine phosphatase 1B inhibitors high-throughput screenin
Aim: A high-throughput screening model was established on 384-well microplate with 50 μL volume in order to screen pote......
OBJECTIVE To screen potential protein tyrosine kinases (PTKs) inhibitors.A high-throughput screening model based on the ......
Conjugated Polythiophene for Rapid,Simple and High-Throughput Screening of Antimicrobial Photosensit
Photodynamic antimicrobial chemotherapy(PACT)is effective for the treatment of pathogenic infections.Here,we present a p......
First Discovery of Novel 3-Hydroxy-quinazoline-2,4(1H,3H)-diones as Specific Anti-Vaccinia and Adeno
The construction of a novel series of 1,2,3-triazolyl 3-hydroxy-quinazoline-2,4(1H,3H)-diones utilizing Cu(I)-catalyzed ......
Droplet-based microfluidics for high-throughput screening of glycosidases and rapid digestion of oli
Glycoside hydrolases (also called glycosidases) are extremely common enzymes with roles in nature including degradation ......
The machine-learning prediction of perovskite ABX3 and A2BBX6 based on the geometric predictor(tolerance factor t)can di......
Hyperactivation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT)signaling promotes tumorige......
近年来多重光学编码技术迅速发展，然而广泛应用于高通量筛选还需要突破诸多限制，其关键是需要满足如下四项要求：1)具有超容量的编......
Intermediate-sensor assisted push-pull strategy and its application in heterologous deoxyviolacein p
Because high-throughput screening tools are typically unavailable when using the pathway-engineering approach,we dev......
Development of Multiplexed Microarray Binding Assay for Agonists and Antagonists of the Estrogen Rec
Estrogen receptors (ERα,ERβ) act in an estrogen-dependent manner to control growth and differentiation of target tissu......
High-throughput screening for compounds for pro-hematopoiesis using zebrafish primary blastomere cul
Generation of hematopoietic stem and progenitor cells in vitro,especially generation of safe therapeutic hematopoietic s......
Arginine deiminase(ADI)catalyzes the hydrolysis of L-arginine to form citrulline and ammonia.As an anti-tumor enzyme......
Covalent ligands modulating protein activities/signals have attracted unprecedented attention in recent years,but th......
A high-throughput assay for screening natural products that enhanceNK cell-mediated killing of cance
Natural killer(NK)cells are central effector lymphocytes of the innate immune system that eliminate transformed cell......
识别新奇人的免疫不全病毒 1 的过程(HIV-1 ) 禁止者为工业、科学的研究提出挑战。因为他们在一幅单个屏幕包括多重目标，在一些，情况......
Traditional two-dimensional(2D)cell cultures lack the extracellular matrix(ECM)-like structure or dynamic fluidic micro-......
目的 为了改变结核分枝杆菌蛋白质的结构与功能研究由于受结核分枝杆菌蛋白难以可溶性表达和纯化的影响而进展缓慢的问题.方法 将......
目的发现新的FKBP52抑制剂类药物,建立以人FKBP52为靶点的高通量药物筛选模型。方法通过大肠埃希菌表达系统重组表达FKBP52蛋白,并......
The protein tyrosine phosphatase Src homology phosphotyrosyl phosphatase 2(SHP2)is implicated in various cancers,and tar......
Based on irreducible representations (or symmetry eigenvalues) and compatibility relations (CR),a material can be predic......
Epithelial-mesenchymal transition (EMT) is a natural phenomenon thatoccurs during embryodevelopment. It is a phenomenon ......
