muscarinic相关论文
Effect of ipratropium bromide on airway and pulmonary muscarinic receptors in a rat model of chronic
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M_(4) muscarinic receptors regulates dopamine/DARPP-32 signaling and glutamate transmis⁃sion to bala
OBJECTIVE Abnormal striatal dopaminergic and glutamatergic neurotransmis⁃sion is central to the pathophysiology of schi......
The development of breast cancer is a complex process that involves the participation of different factors.Several autho......
Objective:To investigate the pharmacological potential of Argemone mexicana in treating constipation and emesis by using......
目的探讨苯环喹溴铵对毒蕈碱样乙酰胆碱受体(M受体)亚型的选择性。方法以表达单一M受体亚型的CHO细胞株进行细胞与[3H]-QNB的饱和......
目的观察细胞膜色谱法是否可以反映药物和毒蕈碱受体结合的特异性和选择性.方法将大鼠心房肌细胞膜固定于硅胶载体表面制备成富含......
目的:研究肥厚型心肌病(HCM)患者血清M2乙酰胆碱能受体自身抗体(M2-AAb)的浓度及其与临床指标的关系.方法:连续入选133例HCM患者为......
目的 观察大鼠慢性阻塞性肺疾病 (COPD)模型气道和肺组织M受体水平 ,以及吸入溴化异丙托品对M受体的影响及其规律。方法 通过长......
三环哌酯盐酸盐(TCPN·HCl)和碘甲烷盐(TCPN·CH3I)为新化学实体。本文以烟碱诱发小鼠惊厥,豚鼠回肠收缩为评价中枢和外周神经元性N受体功能的指......
A technique for studying in vivo the production rate and turnover rate constant of mouse brain M-receptors was establish......
为了探讨毒蕈碱受体(MR)亚型密度变化与不稳定膀胱发生之间的关系,建立不稳定膀胱大鼠模型,采用RT-PCR方法测定不稳定膀胱及对照组......
目的:比较新型抗胆碱化合物盐酸苯环壬酯(CPG)及其衍生物去甲基苯环壬酯(DMCPG)、噻环壬酯(CrG)的抗胆碱作用特点。方法:运用放射性配体受......
目的:对比观察豚鼠左右心房和心室M2胆碱受体的分布位置及其特性。方法:采用M2胆碱受体自身抗体与用人M2胆碱受体肽段经免疫制备的抗受体在......
目的:通过Baculovirus-Sf9 cells系统制备m1AChR-G11融合蛋白和m4AChR-G16融合蛋白,检测几种配体对m1AChR与G11及m4AChR与G16间相......
目的研究慢性小剂量索曼(soman)染毒对大鼠海马和前额叶皮层乙酰胆碱受体m1和m4 mRNA表达的影响。方法以皮下注射索曼为大鼠染毒模型......
目的 从舟山眼镜蛇Naja atra蛇毒中分离毒蕈碱样多肽,探讨其与M胆碱受体的关系。方法 应用分子筛凝胶Sephadex G-50、Sephadex G-10......
兔回肠毒蕈碱性受体的溶脱1曹云鹏2李智张荣强丛华张克义(中国医科大学基础医学院药理学教研室,沈阳110001)理想的受体研究方法是将受体从膜上......
目的制备毒蕈碱乙酰胆碱受体m5亚型与G-蛋白亚单位G11(m5AChR-G11)融合蛋白,探索m5AChR与G11之间的耦联功能、相互作用及其影响因......
目的获得表达人毒蕈碱样乙酰胆碱Ⅰ型受体(hm1R)的工程细胞株(CHO-hm1R)并鉴定表达受体是否具有相应的功能活性.方法以健康人基因......
The urinary bladder is innervated and functionally regulated by the autonomic nervous system. In order to elucidate the ......
目的针对血管内皮细胞上是否存在M受体的疑点,从基因水平和信号转导机理上探讨介导乙酰胆碱(ACh)诱发内皮依赖性血管舒张反应受体......
A Decreased Expression and Functionality of Muscarinic Cholinergic Receptor in Acute Chagas Myocardi
Background: Chagas disease is still a public health problem because of the remaining high prevalence, the expansion of t......
Purpose: To investigate the effects of intravitreal injection of cyclopentolate on form deprivation myopia in guinea pig......
目的:观察预先腹腔注射咪达唑仑对健康成年大鼠和东莨菪碱大鼠大脑皮层及海马组织中胆碱能毒蕈碱样受体(M-R)的近期和远期影响。方法:(1......