rho-kinase相关论文
Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myo
Aim: Inhibition of Rho-kinase displays vasodilation property although its effect on cardiac remodeling in heart against ......
Threonine 532 phosphorylation in ClC-3 is required for angiotensin H-induced Cl- current and migrati
Aim Angiotensin Ⅱ (AngⅡ) induces vascular smooth muscle cell (VSMC) migration and growth, which is responsible for vas......
Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myo
Inhibition of Rho-kinase displays vasodilation property although its effect on cardiac remodeling in heart against press......
Background: Percutaneous carotid artery stenting in the prevention of cerebral vascular diseases are increasingly concer......
RhoA/ROCK pathway regulates canonical transient receptor potential channels in hypoxic pulmonary vas
Aim: Hypoxic pulmonary vasoconstriction (HPV) can be modulated through either elevation of [Ca2+]i by Ca2+-dependent mec......
Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell pr
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Effect of Rho-kinase pathway on neurite outgrowth of rat hippocampal neurons under atomic force micr
Hippocampal neurons of neonatal rats were cultured in serum-free culture medium for 5 days in vitro, and treated with th......
The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral is
The Rho/Rho-kinase signaling pathway plays an important role in cerebral ischemia/reperfusion injury. However, very few ......
目的:探讨Rho激酶活性对急性冠状动脉综合征(ACS)患者长期预后的影响。方法:入选ACS患者280例为观察组,同期冠状动脉(冠脉)造影证......
A Rho-kinase Inhibitor, Fasudil, Attenuates Progressive Glomerulosclerosis Induced by Daunorubicin i
Accumulating evidence suggests that the small G protein Rho and its downstream effector Rho kinase may play important ro......
Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell pr
Background RhoA/ Rho kinase (ROCK) pathway is involved in pulmonary arterial hypertension (PAH) and pulmonary artery smo......
Downregulation of Rho associated coiled-coil forming protein kinase 1 in the process of delayed myoc
Background The connexln43 knockout (Cx43 KO) mouse dies at birth with an enlarged conotruncal region, which leads to the......
Effect of Rho-kinase pathway on neurite outgrowth of rat hippocampal neurons under atomic force micr
Hippocampal neurons of neonatal rats were cultured in serum-free culture medium for 5 days in vitro, and treated with th......
Downregulation of Rho associated coiled-coil forming protein kinase 1 in the process of delayed myoc
Background The connexln43 knockout (Cx43 KO) mouse dies at birth with an enlarged conotruncal region, which leads to the......
目的观察Rho激酶和转化生长因子β（transforming growth factor-β,TGF-β）通路是否参与醛固酮/氯化钠诱导的单肾切除SD大鼠肾脏损伤......
Fasudil (HA-1077) is the first small-molecule inhibitor of Rho-kinase and has been employed for clinical treatment of ce......
目的观察白介素-1β（IL-1β）诱导小型猪冠状动脉内膜增殖时Rho激酶和MCP-1mRNA表达与通心络干预作用。方法24头小型猪随机分为假手术......
目的：探讨NOS／NO、HO／CO、RhoA／Rho激酶等信号通路在自发性高血压大鼠（SHR）阴茎海绵体中的表达及相互关系。方法：健康成年雄性SPF级SHR与......
Role of estrogen receptor β selective agonist in ameliorating portal hypertension in rats with CCl4-
AIM: To investigate the role of diarylpropionitrile(DPN), a selective agonist of estrogen receptor β(ERβ), in liver ci......
目的通过小型猪模型观察白介素-1β（IL-1β）诱导冠状动脉内膜增殖时Rho激酶和p27 mRNA表达的变化及雷帕霉素干预的作用,探讨Rho激酶......
目的探讨Rho激酶活性对急性冠脉综合征（ACS）患者左心功能的影响。方法入选2013年3月至2014年12月间我科收治的ACS患者180例，根据Rho激......
目的观察Rho激酶抑制剂盐酸法舒地尔治疗急性脑梗死的临床疗效和安全性。选择我院2007年7月～2008年4月治疗的急性脑梗死患者60例，随......
目的支架内再狭窄与血管平滑肌分化、迁移，细胞外基质的过度增值所致新生内膜增生密切相关。Rho激酶参与支架置入引起的新生内膜增......
目的观察Rho激酶（ROCKS）特异性抑制剂Y-27632对体外培养的U87胶质瘤细胞侵润能力的影响。方法体外培养U87胶质瘤细胞,采用Transwell......
目的通过Rho激酶（Rhokinase，ROCK）抑制剂干预急性冠脉综合征（acute coronary syndrome，ACS）患者，探讨其对血清白细胞介素37（interleukin-37......
A Rho-kinase Inhibitor, Fasudil, Attenuates Progressive Glomerulosclerosis Induced by Daunorubicin i
Accumulating evidence suggests that the small G protein Rho and its downstream effec-tor Rho kinase may play important r......
目的：研究抑制Rho—kinase对柔红霉素诱导的肾小球硬化的调控作用，并探讨Rho—kinase抑制剂法舒地尔改善肾小球硬化的作用机制。方法......
目的：建立稳定的体外细胞缺氧模型,探讨人体脐静脉内皮细胞（HUVEC）在缺氧条件下RhoA蛋白和Rho激酶对其内皮细胞内皮型一氧化氮合酶（eNO......
Threonine 532 phosphorylation in CIC-3 is required for angiotensin II-induced Cl- current and migrat
Aim Angiotensin II （AngII） induces vascular smooth muscle cell （VSMC） migration and growth, which is responsible for vascula......
Rho通过三磷酸鸟苷（GTP）结合形式和二磷酸鸟苷（GDP）结合形式的转换起着分子开关的作用，调控许多细胞内信号通路。Rho通过激活其下游靶分......
目的 观察Rho-激酶在失血性休克大鼠血管低反应发生中的作用。方法取失血性休克大鼠肠系膜上动脉（SMA），采用离体血管环张力测定技术，观......
研究背景心肌长时间缺血可以导致组织损伤以及细胞死亡,冠状动脉再通是缓解缺血损伤的关键,但较长时间缺血后的再灌注却可导致更为......
第一部分心肌缺血再灌注和缺血预适应中Rho-kinase对PI3-kinase/Akt的作用研究背景心血管疾病一直以来发病率居高不下,在心血管疾......
<正>Rho是小分子量GTPases超家族Rho亚家族成员,是Ras超家族的哺乳动物基因同系物。Rho可以通过其下游效应因子Rho激酶(Rock或Rho-......
期刊
研究背景冠心病已成为我国城乡居民致死的主要原因之一,每年大约70万人死于冠心病,约占全部心血管病死亡的四分之一。再灌注疗法,......
目的：通过Western免疫印迹(Western blot)测定不吸烟的健康人、吸烟但肺功能正常人群、慢性阻塞性肺疾病(chronic obstructive pulm......
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