roflupram相关论文
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in
We have previously shown that roflupram (ROF) protects against MPP+-induced neuronal damage in models of Parkinson\'s ......
目的:脑卒中（stroke）是一种急性的脑损伤疾病,主要表现为脑血管病变引起的脑组织损伤及相关神经功能损伤。目前美国食品药品监督管理......
Roflupram, a PDE4 inhibitor, recues cognitive dysfunction in APP/PS1 transgenic mice via cAMP/PKA/CR
Background: So far,no PDE4 inhibitors in Alzheimers disease has been approved for application in the clinic due to sever......
目的 神经炎症涉及阿尔茨海默病(AD)发病过程,NLRP3/caspase-1/IL-1β炎症通路在其中起重要作用,前期实验研究表明PDE4抑制剂Roflu......
OBJECTIVE Neuroinflammation involes in the pathogenesis of mental disorders and neurodegenerative disorders of central n......
目的 利用抑郁相关的行为绝望模型,进行新型PDE4抑制剂roflupram抗抑郁的药效学初筛.采用慢性不可预见性轻度应激(CUMS)抑郁大鼠模......
目的:阿尔茨海默病(Alzheimer’s disease,AD)是一种起病隐匿的进行性发展的神经系统退行性疾病。脑内老年斑(senileplaques,SPs)......
