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  5. BRCAA1 RNA Nanoparticles for Targeting Imaging and siRNA Therapy of Gastric Cancer

BRCAA1 RNA Nanoparticles for Targeting Imaging and siRNA Therapy of Gastric Cancer

来源 :The 9th Asian Biophysics Association Symposium (ABA2015)(第九届 | 被引量 : 0次 | 上传用户：flordkk
【摘 要】
：
Gastric cancer ranks number two in high incident cancer in China, and is the second leading cause of cancer-related death worldwide.Here we reported the use of
【作 者】
：
Daxiang Cui Chunlei Zhang Bing Liu Yi Shu Tong Du Dan Shu Fangping Dai Beate Saberi Peixuan Guo 
【机 构】
：
InstituteofNanoBiomedicineandEngineering,ShanghaiJiaoTongUniversity,800DongchuanRoad,Shanghai200240,
【出 处】
：
The 9th Asian Biophysics Association Symposium (ABA2015)(第九届
【发表日期】
：
2015年5期
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Gastric cancer ranks number two in high incident cancer in China, and is the second leading cause of cancer-related death worldwide.Here we reported the use of bacteriophage phi29 DNA packaging motor pRNA three-way junction (3WJ) to escort folic acid, NIR image marker and BRCAA1 siRNA for targeting, imaging, delivery, gene silencing and regression of gastric cancer in animal models.In vitro assay revealed that the RNA nanoparticles specifically bind to gastric cancer cells MGC803, and the BRCAA1 gene was significantly silenced by the siRNA incorporated in the RNA nanoparticles.The apoptosis of gastric cancer cells was confirmed by the finding of silencing of anti-apoptosis factor BCl-2 and up-regulation expression of the proapoptosis factor Rb and Bax.
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