Sterol Peroxidation the Formation of Toxic Oxysterols as a Consequence of Genetics or Small Molecule

来源 :2016上海脂代谢与疾病国际研讨会 | 被引量 : 0次 | 上传用户：echo1108

【摘要】

：

7-Dehydrocholesterol (7-DHC) is the most oxidizable lipid known and its derived oxysterols may be critical to the pathobiology of Smith-Lemli-Opitz Syndrome (SL

【作者】

：

Ned A. Porter

【机构】

：

DepartmentofChemistryandtheVanderbiltInstituteofChemicalBiology,VanderbiltUniversity,Nashville,TN,US

【出处】

：

2016上海脂代谢与疾病国际研讨会

【发表日期】

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2016年9期

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7-Dehydrocholesterol (7-DHC) is the most oxidizable lipid known and its derived oxysterols may be critical to the pathobiology of Smith-Lemli-Opitz Syndrome (SLOS,a recessive neurodevelopmental disorder caused by mutations in the gene encoding 3-hydroxysterol-reductase (DHCR7;EC 1.3.1.21).

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Sterol Peroxidation the Formation of Toxic Oxysterols as a Consequence of Genetics or Small Molecule

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