【摘 要】
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A major problem with cisplatin treatment is the development of acquired-drug resistance of the tumour cells.Verotoxin1 (VT-1) exerts its cytotoxicity by tar
【机 构】
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Department of Medical Biosciences, Clinical Chemistry Ume(a) University Sweden
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A major problem with cisplatin treatment is the development of acquired-drug resistance of the tumour cells.Verotoxin1 (VT-1) exerts its cytotoxicity by targeting the membrane glycolipid globotriasosylceramide (Gb3), a molecule associated with drug resistance.Cisplatin-and VT-1-induced apoptosis involves mitogen-activated protein kinase (MAPK) activation, and deactivation of MAPKs is associated with cisplatin resistance.We therefore aimed to investigate whether a sub-toxic concentration of VT-1 could enhance cisplatin-induced apoptosis and overcome acquired-cisplatin resistance in cultured cancer cell lines.
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