【摘 要】
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The pathogenetic link between iron overload and diabetes or increased mortality may be exerted through iron-catalysed formation of hydroxyl radicals via the Fenton reaction and ensuing tissue oxidativ
【机 构】
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Faculty of Health and Medical Sciences University of Copenhagen Denmark
【出 处】
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2013百奥泰波兰重大疾病临床峰会
论文部分内容阅读
The pathogenetic link between iron overload and diabetes or increased mortality may be exerted through iron-catalysed formation of hydroxyl radicals via the Fenton reaction and ensuing tissue oxidative stress.It has been shown that urinary excretion of oxidised RNA-a biomarker of oxidative stress-is associated with increased mortality in patients with diabetes or patients with hemochromatosis -an iron overload disease.We present data from two population-based studies (N=40,000) and two diabctcs-patient-based studies (N=7,000) on risk of diabetes and total mortality according to iron overload and hemochromatosis genotypes.Conclusions: hereditary haemochromatosis is a disease generally overlooked in patients with late-onset type 1 diabetes mellitus, a late manifestation of iron overload.Elevated transferrin saturation confers a 2-3 fold increased risk of developing any form of diabetes metlitus, as well as Type 1 diabetes and Type 2 diabetes separately.Individuals in the general population with TS ≥3d50% versus <50% have an increased risk of premature death.Individuals with diabetes, ascertained in the general population and in specialized diabetes clinics.with increased TS or hemochromatosis genotype have a 2-6-fold increased risk of premature death.Thus, we recommend targeted screening with TS or hemochromatosis genotype in individuals with diabetes in the general population and in specialized diabetes clinics.
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