【摘 要】
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Objective: HOTAIR, a long intervening non-coding RNA (lincRNA), associates with the Polycomb Repressive Complex 2 (PRC2) and is reported to reprogram chromatin organization and promote tumor progressi
【机 构】
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210011 南京医科大学第二附属医院肿瘤科 210029 南京医科大学生化与分子生物学系
【出 处】
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第十七届全国临床肿瘤学大会暨2014年CSCO学术年会
论文部分内容阅读
Objective: HOTAIR, a long intervening non-coding RNA (lincRNA), associates with the Polycomb Repressive Complex 2 (PRC2) and is reported to reprogram chromatin organization and promote tumor progression.However, little is known about the roles of this gene in the development of chemoresistance phenotype of lung adenocarcinoma (LAD).Thus, we investigated the involvement of HOTAIR in the resistance of LAD cells to cisplatin.Method: In the present study, qRT-PCR assay was performed todetect the expression of HOTAIR in cisplatin-resistant A549/DDP, its parental A549 and another LAD cell line SPC-A1.
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