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  5. Study on action mechanism of a dual-effect inhibitor against both wild-type and drug-resistant mutan

Study on action mechanism of a dual-effect inhibitor against both wild-type and drug-resistant mutan

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：LUOMINGGANG818
【摘 要】
：
Background: HIV-1 integrase (IN), which responsible for strand transfer (ST) reaction by inserting the viral DNA into host cell DNA, has become an important target for antiviral drug discovery.However
【作 者】
：
张小轶 刘洋 刘明 李杉 王存新 
【机 构】
：
生命科学与生物工程学院,北京工业大学,北京,100124 药物研究所,中国医学科学院,北京,100
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
HIV-1 integrase drug resistance dual-effect inhibitor action mechanism 
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　　Background: HIV-1 integrase (IN), which responsible for strand transfer (ST) reaction by inserting the viral DNA into host cell DNA, has become an important target for antiviral drug discovery.However, mutants have emerged, such as N155H/S, which confer resistance to FDA approved diketo-acid (DKA) drugs (RAL, EVG, DTG) and other DKA inhibitors.
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