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  5. Transcription factor and microRNA co-regulatory network analysis in complex diseases

Transcription factor and microRNA co-regulatory network analysis in complex diseases

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：lilinjun0954
【摘 要】
：
Background: Transcription factors (TFs) and microRNAs (miRNAs) can jointly regulate target gene expression in the forms of feed-forward loops (FFLs) or feedback loops (FBLs).These regulatory loops ser
【作 者】
：
张红梅 叶华山 龚静 刘伟 郭安源 
【机 构】
：
湖北省生物信息与分子成像重点实验室,生物医学工程系,生命科学与技术学院,华中科技大学,武汉,430074
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
feed-forward loop microRNA regulatory network T-ALL transcription factor 
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　　Background: Transcription factors (TFs) and microRNAs (miRNAs) can jointly regulate target gene expression in the forms of feed-forward loops (FFLs) or feedback loops (FBLs).These regulatory loops serve as important motifs in gene regulatory networks and play critical roles in multiple biological processes and different diseases.Some of the TF-miRNA mediated regulatory modules have been verified.However, there are no TF-miRNA analysis in T-cell acute lymphoblastic leukemia (T-ALL) and no comprehensive review of the TF-miRNA network.
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