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Post-dilation often is performed following stent deployment to improve stent expansion.However, aggressive mechanical expansion causes microvascular injury, especially for acute myocardial infarction (AMI) patients.Few studies have investigated the effects of post-dilation on medium-term clinical outcomes.Patients enrolled in the multicenter National Heart, Lung, and Blood Institute Dynamic Registry between 2001 and 2006 were evaluated.Patients who had a single de novo lesion treated successfully with 1 stent were studied.Patients were followed up to 1-year.